Biocatalysis in the Pharmaceutical and Biotechnology Industries

Biocatalysis in the Pharmaceutical and Biotechnology Industries PDF

Author: Ramesh N. Patel

Publisher: CRC Press

Published: 2006-09-26

Total Pages: 878

ISBN-13: 1420019376

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Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemic

Biocatalysis for the Pharmaceutical Industry

Biocatalysis for the Pharmaceutical Industry PDF

Author: Junhua (Alex) Tao

Publisher: John Wiley & Sons

Published: 2009-07-23

Total Pages: 250

ISBN-13: 0470823151

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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Biocatalytic Membrane Reactors

Biocatalytic Membrane Reactors PDF

Author: Enrico Drioli

Publisher: CRC Press

Published: 2020-10-07

Total Pages: 232

ISBN-13: 1000124096

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This research level reference book has been co-written by Enrico Drioli, perhaps one of the world's best known researchers into membrane technology. The application of membrane technology to chemical transformation and molecular separation are beginning to be exploited in the pharmaceutical science and biotechnology industries, but there is a need for researchers and students to have up-to-date literature - and this book provides it. The book will be of interest to students of chemistry, chemical engineering, pharmacy and biotechnology.

Biocatalysis

Biocatalysis PDF

Author: Gonzalo de Gonzalo

Publisher: Royal Society of Chemistry

Published: 2017-11-02

Total Pages: 532

ISBN-13: 1782626190

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Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Biocatalysis for Practitioners

Biocatalysis for Practitioners PDF

Author: Gonzalo de Gonzalo

Publisher: John Wiley & Sons

Published: 2021-07-19

Total Pages: 54

ISBN-13: 352734683X

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This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis PDF

Author: Peter Grunwald

Publisher: CRC Press

Published: 2020-11-26

Total Pages: 424

ISBN-13: 1000067386

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Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.

Applied Biocatalysis

Applied Biocatalysis PDF

Author: Lutz Hilterhaus

Publisher: John Wiley & Sons

Published: 2016-07-27

Total Pages: 400

ISBN-13: 3527677143

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This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Biocatalysis for Green Chemistry and Chemical Process Development

Biocatalysis for Green Chemistry and Chemical Process Development PDF

Author: Junhua (Alex) Tao

Publisher: John Wiley & Sons

Published: 2011-06-09

Total Pages: 494

ISBN-13: 1118028295

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This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

Industrial Biocatalysis

Industrial Biocatalysis PDF

Author: Peter Grunwald

Publisher: CRC Press

Published: 2014-12-11

Total Pages: 1201

ISBN-13: 9814463892

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Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts-with

Biocatalysis and Biotechnology for Functional Foods and Industrial Products

Biocatalysis and Biotechnology for Functional Foods and Industrial Products PDF

Author: Ching T. Hou

Publisher: CRC Press

Published: 2006-12-26

Total Pages: 563

ISBN-13: 9780849392825

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Biocatalysis and biotechnology are rapidly advancing areas of research with the significant advantages of high specificity, efficiency, energy conservation, and pollution reduction. With applications in industrial processes and the huge world nutraceutical and functional food market, of which the US alone is responsible for more than $100 billion per year, this is clearly a domain that needs a comprehensive reference for the current knowledge in the field. Biocatalysis and Biotechnology for Functional Foods and Industrial Products is an in-depth collection of reviews of the current advances in biocatalysis and biotechnology as presented at the International Symposium on Biocatalysis and Biotechnology held at the National Chung Hsing University, Taichung, Taiwan in October 2005. With an emphasis on functional foods and industrial products, this is the most current compendium available. Internationally recognized scientists from US, Japan, Korea, Iceland, Germany, and Taiwan share their valuable research results on topics within the general definition of biocatalysis and biotechnology. Covering the latest applications for enzyme catalysis, biotransformation, bioconversion, fermentation, genetic engineering, and product recovery, this book outlines one-step catalytic reactions as well as many sequential reaction steps involved in production. Divided into two sections, the first presents cutting edge information on functional food research including health food, nutritional supplements, and nutraceuticals. Chapters include enzymatic fractionation, chemoenzymatic synthesis, and novel biofunctions for functional nutrients. The second section is devoted to industrial applications such as the biotransformation of aliphatic hydrocarbons, biodegradable industrial lubricants, and the stabilization of living microbial biological control agents for insecticides. Providing a comprehensive review of the modern development of biocatalysis and biotechnology, Biocatalysis and Biotechnology for Functional Foods and Industrial Products is a valuable reference for researchers and scientists as well as an indispensable introduction of the state-of-the-science for newcomers to the field.