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Bacterial Signaling

Author: Reinhard Krämer

Publisher: John Wiley & Sons

Published: 2009-12-09

Total Pages: 513

ISBN-13: 3527629246

Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.

Bacterial Sensing and Signaling

Author: Mattias Collin

Publisher: Karger Medical and Scientific Publishers

Published: 2009-01-01

Total Pages: 239

ISBN-13: 3805591322

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Over the last fifteen years it has become increasingly obvious that bacteria are not as simple and solitary as once believed. Rather, an accumulating body of work shows that bacteria are highly complicated and social organisms, constantly sensing their surroundings and altering both their environments and behaviors to ensure survival. Direct communication between bacteria turns out to be quite common, as are coordinated intra- and interspecies responses that include the formation of highly sophisticated microbial communities. In fact, threats to bacterial survival from assaults ranging from nutrient deprivation and oxygen depletion tothe defenses of eukaryotic hostsare all managed through the integration of a dizzying array of complex sensory and communication systems with the appropriate bacterial behaviors. This volume provides an update of the current knowledgeinthe expanding field ofbacterial sensing and signaling, highlighting its most important and interesting aspects. In twelve state-of-the-art articles, respected international experts address topics such as quorum sensing and secondary messengers, chemotaxis and magnetoaerotaxis, two-component phosphotransferase systems, bacterial virulence mechanisms, thermoregulation, and more. The final chapter represents a unique description of the tools available to manipulate many of the sensing and signaling systems described in this volume. Bacterial Sensing and Signaling is recommended reading for students, scientists and clinicians with interests in microbiology, immunology, ecology, biotechnology and a range of other disciplines.

Bacterial Signal Transduction: Networks and Drug Targets

Author: Ryutaro Utsumi

Publisher: Springer

Published: 2008-06-06

Total Pages: 242

ISBN-13: 9780387788845

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This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.

Receptor Signaling and Adaptation in Bacterial Sensing

Author: Andrew Frank Russo

Publisher:

Published: 1984

Total Pages: 426

ISBN-13:

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Bacterial Cell-to-Cell Communication

Author: Donald R. Demuth

Publisher: Cambridge University Press

Published: 2006-02-23

Total Pages: 340

ISBN-13: 9781139447973

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Many bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks.

Bacterial Sensors

Author: Jan Roelof van der Meer

Publisher: Springer Nature

Published: 2022-05-31

Total Pages: 153

ISBN-13: 3031025709

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Bacterial reporters are live, genetically engineered cells with promising application in bioanalytics. They contain genetic circuitry to produce a cellular sensing element, which detects the target compound and relays the detection to specific synthesis of so-called reporter proteins (the presence or activity of which is easy to quantify). Bioassays with bacterial reporters are a useful complement to chemical analytics because they measure biological responses rather than total chemical concentrations. Simple bacterial reporter assays may also replace more costly chemical methods as a first line sample analysis technique. Recent promising developments integrate bacterial reporter cells with microsystems to produce bacterial biosensors. This lecture presents an in-depth treatment of the synthetic biological design principles of bacterial reporters, the engineering of which started as simple recombinant DNA puzzles, but has now become a more rational approach of choosing and combining sensing, controlling and reporting DNA 'parts'. Several examples of existing bacterial reporter designs and their genetic circuitry will be illustrated. Besides the design principles, the lecture also focuses on the application principles of bacterial reporter assays. A variety of assay formats will be illustrated, and principles of quantification will be dealt with. In addition to this discussion, substantial reference material is supplied in various Annexes. Table of Contents: Short History of the use of Bacteria for Biosensing and Bioreporting / Genetic Engineering Concepts / Measuring with Bioreporters / Epilogue

Bacteria Sensing, Signaling, Memory, and Appendages During Biofilm Formation

Author: Calvin Kai-man Lee

Publisher:

Published: 2020

Total Pages: 279

ISBN-13:

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Bacterial biofilms are surface-adhered communities or suspended aggregates of bacteria that have increased tolerance to environmental stresses and antibiotics. These biofilms can be harmful by causing diseases and can be beneficial by serving as commensals and having bioremediation and energy applications. Throughout the formation of a biofilm, bacteria utilize different appendages, such as flagella and type IV pili (TFP), to engage in various behaviors, such as motility, interaction with their environments or neighboring cells, and responding to chemical gradients. These appendages and their associated motor machinery then activate cellular responses that are primarily controlled by intracellular secondary messenger molecules, such as cyclic diguanylate (c-di-GMP) and cyclic AMP (cAMP). In this dissertation, we investigate the complex spatiotemporal interplay between appendages and secondary messengers in bacterial sensing systems during biofilm formation. We develop a new technique to image how appendage activity impacts motility in single cells in 3D at high time resolution for cells near a surface and reveal an unexpected taxonomy of appendage-driven surface motility mechanisms. We find that sensing generally involves a complicated network of events that span different length and time scales, where appendage activity and secondary messenger production are mutually coupled to one another to generate feedback circuits. These complex couplings between bacterial signals and responses can propagate across generations of cellular division in a kind of memory or communication between ancestors and descendants. We develop a quantitative framework with stochastic models to analyze these coupled spatiotemporal correlations and behaviors, and our results indicate a social dimension to the strategies employed by bacteria while sensing and colonizing a surface. Furthermore, we find that bacterial appendages, in addition to sensing and motility, can also influence metabolism and impact cell size homeostasis during biofilm growth. Our quantitative framework can be applied to other bacterial systems to understand how they utilize their cellular machinery for orchestrating different types of social cooperativity while utilizing different surface colonization strategies. With this framework, we can understand the foundational basis for biofilm formation in terms of the complex interplay across time and space between appendage activity and secondary messenger signaling in bacteria sensing systems.

Quorum Sensing

Author: Giuseppina Tommonaro

Publisher: Academic Press

Published: 2019-04-08

Total Pages: 309

ISBN-13: 012814906X

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Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals. Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists. Describes Quorum Sensing (QS) mechanisms from their molecular basis, to their clinical applications Spans several fields in relation to QS, including microbiology, chemistry, biochemistry and ecology Considers QS as an approach to the discovery of new antibiotics Looks at QS as a means to understand the microbial world and towards use of bacteria and their products in biotechnological applications Summarizes key results on QS mechanisms’ molecular basis and fields of application

Microbial Signalling and Communication

Author: Society for General Microbiology. Symposium

Publisher: Cambridge University Press

Published: 1999-05-06

Total Pages: 386

ISBN-13: 9780521652612

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Presents information at the forefront of this exciting field and includes contributions on a range of organisms and signalling molecules.

Implication of Quorum Sensing System in Biofilm Formation and Virulence

Author: Pallaval Veera Bramhachari

Publisher: Springer

Published: 2019-01-28

Total Pages: 381

ISBN-13: 9811324298

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This book illustrates the importance and significance of Quorum sensing (QS), it’s critical roles in regulating diverse cellular functions in microbes, including bioluminescence, virulence, pathogenesis, gene expression, biofilm formation and antibiotic resistance. Microbes can coordinate population behavior with small molecules called autoinducers (AHL) which serves as a signal of cellular population density, triggering new patterns of gene expression for mounting virulence and pathogenesis. Therefore, these microbes have the competence to coordinate and regulate explicit sets of genes by sensing and communicating amongst themselves utilizing variety of signals. This book descry emphasizes on how bacteria can coordinate an activity and synchronize their response to external signals and regulate gene expression. The chapters of the book provide the recent advancements on various functional aspects of QS systems in different gram positive and gram negative organisms. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with quorum sensing signal molecules viz. virulence, pathogenesis, antibiotic synthesis, biosurfactants production, persister cells, cell signaling and biofilms, intra and inter-species communications, host-pathogen interactions, social interactions & swarming migration in biofilms.