Autophagy in Autoimmunity
Author: Xu-jie Zhou
Publisher: Frontiers Media SA
Published: 2019-05-15
Total Pages: 161
ISBN-13: 2889458121
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Autophagy Networks in Inflammation
Author: Maria Chiara Maiuri
Publisher: Springer
Published: 2016-08-17
Total Pages: 409
ISBN-13: 3319300792
DOWNLOAD EBOOK →Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
Autophagy and NF-[kappa]B Activation in Autoimmunity
Author: Dennis Jau-Tyng Wu
Publisher:
Published: 2017
Total Pages:
ISBN-13: 9781369795493
DOWNLOAD EBOOK →Recently, autophagy-related genes polymorphisms have been implicated in several autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and multiple sclerosis. Autophagy is the highly conserved protein degradation pathway from yeasts to humans and is essential for removing protein aggregates, misfold proteins in healthy cells. More and more studies reveal autophagy and autophagy-related proteins also participate in immune regulation, such as removal of intracellular bacteria, inflammatory cytokine secretion, antigen presentation, and lymphocyte development. The generation of autophagy-related protein knockout mice advances our understanding of autophagy in the immune system and autoimmunity tremendously. For instance, autophagy-related proteins deficient mice are protected from experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, and autophagy-related proteins deficient mice are protected from TNF[alpha] joint destruction in experimental arthritis. One of the links between autophagy and autoimmune diseases is activation of nuclear factor [kappa]B (NF-[kappa]B). Autophagy has been shown to regulate NF-[kappa]B activation while NF-[kappa]B activation often leads to autoimmune disease pathogenesis. In this article, we explore the role of a novel autophagy-related protein WDFY3 in NF-[kappa]B activation and an animal model of autoimmune diseases. More detailed understanding the role of autophagy and autophagy-related proteins is needed for developing therapeutic interventions target autophagy pathway/autophagy proteins for autoimmune diseases.
Mosaic of Autoimmunity
Author: Carlo Perricone
Publisher: Academic Press
Published: 2019-02-15
Total Pages: 728
ISBN-13: 012814307X
DOWNLOAD EBOOK →The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications
Autophagy: Biology and Diseases
Author: Weidong Le
Publisher: Springer Nature
Published: 2020-07-15
Total Pages: 734
ISBN-13: 9811542724
DOWNLOAD EBOOK →This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine
Autophagy Regulation of Innate Immunity
Author: Jun Cui
Publisher: Springer Nature
Published: 2019-11-14
Total Pages: 203
ISBN-13: 981150606X
DOWNLOAD EBOOK →This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.
Autophagy, Infection, and the Immune Response
Author: William T. Jackson
Publisher: John Wiley & Sons
Published: 2014-12-03
Total Pages: 352
ISBN-13: 1118677714
DOWNLOAD EBOOK →The relationship between infection and immunity and autophagy, a pathway of cellular homeostasis and stress response, has been a rapidly growing field of study over the last decade. While some cellular processes are pro- or anti-infection, autophagy has been proven to be both: a part of the innate immune response against some microbes, and a cellular pathway subverted by some pathogens to promote their own replication. Autophagy, Infection, and the Immune Response provides a unified overview of the roles of cellular autophagy during microbial infection. Introductory chapters ground the reader by delineating the autophagic pathway from a cellular perspective, and by listing assays available for measuring autophagy. Subsequent chapters address virus interactions with autophagy machinery, the various roles of autophagy parasitic infection, and interactions of bacteria with the autophagic pathway. Concluding chapters explore the relationships of autophagy to systemic immune responses, including antigen presentation, ER stress, and production of IFN-gamma. Designed as a resource for those interested in initiating studies on the relationship between autophagy and infection or immunity, Autophagy, Infection, and the Immune Response combines practical state-of the art technique descriptions with an overview of the wide variety of known interactions between pathogens and the autophagic pathway.
Autophagy in Immunity and Infection
Author: Vojo Deretic
Publisher: John Wiley & Sons
Published: 2006-08-21
Total Pages: 286
ISBN-13: 3527608540
DOWNLOAD EBOOK →This first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also covering emerging infectious diseases, such as tuberculosis. Edited by one of the authors of a groundbreaking paper on this topic.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Author: M. A. Hayat
Publisher: Elsevier
Published: 2013-09-03
Total Pages: 435
ISBN-13: 0124115144
DOWNLOAD EBOOK →Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process. Volumes in the Series
Autophagy in Immune Response: Impact on Cancer Immunotherapy
Author: Salem Chouaib
Publisher: Academic Press
Published: 2020-05-11
Total Pages: 242
ISBN-13: 0128227575
DOWNLOAD EBOOK →Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies. Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators
