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Autophagy and Senescence in Cancer Therapy

Author:

Publisher: Academic Press

Published: 2021-04-13

Total Pages: 384

ISBN-13: 0128241594

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy

Author: Patrizia Agostinis

Publisher: Frontiers Media SA

Published: 2018-02-19

Total Pages: 111

ISBN-13: 2889454223

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Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author: M. A. Hayat

Publisher: Academic Press

Published: 2017-09-07

Total Pages: 622

ISBN-13: 0128121475

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms. Presents the most advanced information regarding the role of the autophagic system in life and death States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease Authored by global leaders in the field, bringing the broadest, most expert coverage available

Apoptosis, Senescence and Cancer

Author: David A. Gewirtz

Publisher: Springer Science & Business Media

Published: 2007-10-23

Total Pages: 596

ISBN-13: 1597452211

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This book provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author: M. A. Hayat

Publisher: Academic Press

Published: 2016-12-28

Total Pages: 430

ISBN-13: 0128094273

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Senescence

Author: Jolanta Dorszewska

Publisher: BoD – Books on Demand

Published: 2017-08-30

Total Pages: 167

ISBN-13: 9535134612

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In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Geriatric Oncology

Author: Martine Extermann

Publisher: Springer

Published: 2020-01-30

Total Pages: 1150

ISBN-13: 9783319574141

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This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.