Auto-Inflammatory Syndromes

Auto-Inflammatory Syndromes PDF

Author: Petros Efthimiou

Publisher: Springer

Published: 2019-01-04

Total Pages: 322

ISBN-13: 3319969293

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This book provides an overview of auto-inflammatory syndromes, covering the underlying immune mechanisms that lead to their development, specific disease presentations, and clinical treatment guidelines. The book is divided into two sections, adult and pediatric, with chapters focusing on individuals diseases such as systemic arthritis, hyper-IgD, pap syndrome, idiopathic recurrent pericarditis, and familial Mediterranean fever. Chapters incorporate the most recent advances in disease pathophysiology and examine the underlying inductive and effector mechanisms and therapies that relate to each auto-inflammatory disorder at the genetic, molecular, cellular, and epidemiologic levels. The book also discusses the research behind auto-inflammatory disorders to offer detailed clinical guidelines regarding diagnostic techniques, treatment plans, and advice on how to best transition pediatric patients into adult treatment. This is an invaluable reference on auto-inflammatory syndromes for clinicians and researchers in pediatric and adult rheumatology and immunology.

Textbook of Autoinflammation

Textbook of Autoinflammation PDF

Author: Philip J. Hashkes

Publisher: Springer

Published: 2019-02-13

Total Pages: 820

ISBN-13: 3319986058

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This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

Rheumatic Disease in Geriatrics

Rheumatic Disease in Geriatrics PDF

Author: Gleb Slobodin

Publisher: Springer Nature

Published: 2020-05-25

Total Pages: 391

ISBN-13: 3030442349

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This book provides a practical guide to the diagnosis and management of rheumatic disease in geriatric patients. It details information on the effect of ageing on musculoskeletal and immune systems and specifies impact of a variety of inflammatory and degenerative rheumatic disorders on the elderly. The clinical diagnostic approach to an older individual with musculoskeletal complaints is a cornerstone of this book, which includes also insights into the most important comorbidities for this age and discusses in depth available treatments and rehabilitation tools. The symptoms, imaging features and recommendations on the interpretation of specific laboratory tests for rheumatic diseases in geriatrics are also covered. This book encompasses traditionally associated with older age conditions including temporal arteritis, polymyalgia rheumatica, osteoarthritis, as well as common systemic autoimmune diseases that can produce atypical manifestations in the elderly. It will enable the readers to develop a thorough understanding of how to deal with these patients in their clinical practice. Rheumatic Disease in Geriatrics: Diagnosis and Management systematically describes how to diagnose and treat geriatric patients with a variety of rheumatic conditions and is a valuable resource for all medical professionals involved.

Inpatient Dermatology

Inpatient Dermatology PDF

Author: Misha Rosenbach

Publisher: Springer

Published: 2018-11-03

Total Pages: 415

ISBN-13: 3319184490

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​​​ Inpatient Dermatology is a concise and portable resource that synthesizes the most essential material to help physicians with recognition, differential diagnosis, work-up, and treatment of dermatologic issues in the hospitalized patient. Complete with hundreds of clinical and pathologic images, this volume is both an inpatient dermatology atlas and a practical guide to day-one, initial work-up, and management plan for common and rare skin diseases that occur in the inpatient setting. Each chapter is a bulleted, easy-to-read reference that focuses on one specific inpatient dermatologic condition, with carefully curated clinical photographs and corresponding histopathologic images to aid readers in developing clinical-pathologic correlation for the dermatologic diseases encountered in the hospital. Before each subsection the editors share diagnostic pearls, explaining their approach to these challenging conditions. This book is structured to be useful to physicians, residents, and medical students. It spans dermatology, emergency medicine, internal medicine, infectious disease, and rheumatology. Inpatient Dermatology is the go-to guide for hospital-based skin diseases, making even the most complex inpatient dermatologic issues approachable and understandable for any clinician.

Primary and Secondary Immunodeficiency

Primary and Secondary Immunodeficiency PDF

Author: Jonathan A. Bernstein

Publisher: Springer Nature

Published: 2021-01-28

Total Pages: 409

ISBN-13: 3030571572

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This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.

Rheumatology in Questions

Rheumatology in Questions PDF

Author: Haralampos M. Moutsopoulos

Publisher: Springer

Published: 2018-02-13

Total Pages: 187

ISBN-13: 3319716042

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This book covers all fields in rheumatology and aims to help readers comprehend, familiarize and evaluate their knowledge of the subject area. It contains short questions and concise answers on definitions, pathogenetic aspects, clinical and laboratory manifestations, differential diagnosis and the management of all rheumatic diseases. The book also provides questions and answers on major aspects of basic immunology, valuable for understanding underlying immunological mechanisms of autoimmune rheumatic diseases. Illustrations and images help present information in a clear and schematic way.

Autoinflammatory Disorders, an Issue of Dermatologic Clinics

Autoinflammatory Disorders, an Issue of Dermatologic Clinics PDF

Author: William Abramovits

Publisher: Elsevier Health Sciences

Published: 2013-07-28

Total Pages: 315

ISBN-13: 1455775894

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Autoinflammatory diseases are caused by primary dysfunction of the innate immune system, with overlapping symptoms that make diagnosis difficult. This issue of the Dermatologic Clinics offers and introduction to Autoinflammatory Diseases, along with articles on the role of genetics, diagnosing these diseases, managing them from a dermatologic, pediatric, and rheumatologic standpoint and the various treatment options available.

Systemic Autoinflammatory Diseases—Clinical Rheumatic Challenges

Systemic Autoinflammatory Diseases—Clinical Rheumatic Challenges PDF

Author: Eugen Feist

Publisher:

Published: 2021

Total Pages: 266

ISBN-13: 9783036525617

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Autoinflammation, as a relatively new field in clinical rheumatology, has gained an increasing importance in recent years. The number of identified entities and affected patients has gradually increased, and some of the involved pathways have already been identified. This progress allows a deeper understanding of closely linked diseases, namely, inflammasomopathies, interferonopathies, Relo-pathies, and proteasome associated syndromes. These insights have not only improved their classification but also helped to identify new treatment targets of pro-inflammatory cytokines, including IL-1ß, IL-6, interferon-, and TNF-alpha. Nevertheless, there is still a high medical need, especially in reliable outcome measures, for confirmation of data from controlled clinical trials and, finally, also for long-term experience from registers. This issue welcomes all types of papers on the broad spectrum of clinical characteristics, prognosis, pathophysiology, and treatment of autoinflammatory diseases. The goal of this Special Issue is to further raise awareness of autoinflammatory processes and to better separate them from well-established autoimmune diseases. It is clear that we have entered a new age in this complex field, linking rheumatology even closer to immunology.

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