A Handbook of Applied Statistics in Pharmacology

A Handbook of Applied Statistics in Pharmacology PDF

Author: Katsumi Kobayashi

Publisher: CRC Press

Published: 2012-10-18

Total Pages: 232

ISBN-13: 157808752X

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Statistics plays an important role in pharmacology and related subjects such as toxicology and drug discovery and development. Improper statistical tool selection for analyzing the data obtained from studies may result in wrongful interpretation of the performance or safety of drugs. This book communicates statistical tools in simple language. The examples used are similar to those that scientists encounter regularly in their research area. The authors provide cognitive clues for selection of appropriate tools to analyze the data obtained from the studies and explain how to interpret the result of the statistical analysis.

Applied Statistics in Toxicology and Pharmacology

Applied Statistics in Toxicology and Pharmacology PDF

Author: Katsumi Kobayashi

Publisher:

Published: 2003

Total Pages: 0

ISBN-13: 9781578083046

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This book will serve as an excellent field guide to applied toxicology and pharmacology investigators. It is an easy-to-read compilation of topics in applied statistics that might be considered a FAQ or perhaps more properly, a compilation of answers to questions that should be frequently asked, but often are not.

Applied Statistics in the Pharmaceutical Industry

Applied Statistics in the Pharmaceutical Industry PDF

Author: Steven P. Millard

Publisher: Springer

Published: 2001-07-01

Total Pages: 515

ISBN-13: 0387988149

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Providing a general guide to statistical methods used in the pharmaceutical industry, and illustrating how to use S-PLUS to implement these methods, the book explains why S-PLUS is a useful software package and discusses the results and implications of each particular application. It is targeted at graduates in biostatistics, statisticians involved in the industry as research scientists, regulators, academics, and/or consultants who want to know more about how to use S-PLUS and learn about other sub-fields within the industry, as well as statisticians in other fields who want to know more about statistical applications in the pharmaceutical industry.

Nonclinical Statistics for Pharmaceutical and Biotechnology Industries

Nonclinical Statistics for Pharmaceutical and Biotechnology Industries PDF

Author: Lanju Zhang

Publisher: Springer

Published: 2016-01-13

Total Pages: 705

ISBN-13: 3319235583

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This book serves as a reference text for regulatory, industry and academic statisticians and also a handy manual for entry level Statisticians. Additionally it aims to stimulate academic interest in the field of Nonclinical Statistics and promote this as an important discipline in its own right. This text brings together for the first time in a single volume a comprehensive survey of methods important to the nonclinical science areas within the pharmaceutical and biotechnology industries. Specifically the Discovery and Translational sciences, the Safety/Toxiology sciences, and the Chemistry, Manufacturing and Controls sciences. Drug discovery and development is a long and costly process. Most decisions in the drug development process are made with incomplete information. The data is rife with uncertainties and hence risky by nature. This is therefore the purview of Statistics. As such, this book aims to introduce readers to important statistical thinking and its application in these nonclinical areas. The chapters provide as appropriate, a scientific background to the topic, relevant regulatory guidance, current statistical practice, and further research directions.

Statistics in Toxicology Using R

Statistics in Toxicology Using R PDF

Author: Ludwig A. Hothorn

Publisher: CRC Press

Published: 2016-01-13

Total Pages: 294

ISBN-13: 1498786758

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The apparent contradiction between statistical significance and biological relevance has diminished the value of statistical methods as a whole in toxicology. Moreover, recommendations for statistical analysis are imprecise in most toxicological guidelines. Addressing these dilemmas, Statistics in Toxicology Using R explains the statistical analysi

Statistics In the Pharmaceutical Industry, 3rd Edition

Statistics In the Pharmaceutical Industry, 3rd Edition PDF

Author: Charles Ralph Buncher

Publisher: CRC Press

Published: 1993-11-17

Total Pages: 606

ISBN-13: 9780824790738

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This rewritten and updated second edition provides comprehensive information on the wide-ranging applications of statistics in the pharmacological field. Focusing on practical aspects, it sets out to bridge the gap between industry and academia.;Reflecting the changes that have taken place since publication of the first edition, this volume covers new topics such as: cancer clinical trials, clinical trials of AIDS patients and animal tumorigenicity studies; the development of antiepileptic drugs; the role of epidemiology in postmarketing trials and adverse drug experience; computer-assisted new drug application (CANDA) submissions; contract research organizations; interim analysis in clinical trials; and room-temperature tests for the stability of drugs.;This work is intended as: a reference for statisticians, biostatisticians, pharmacologists, administrators, managers, and scientists in the pharmaceutical industry; and a text for graduate students taking courses in applied statistics or pharmaceutical statistics.

Statistical Methods in Toxicology

Statistical Methods in Toxicology PDF

Author: Ludwig Hothorn

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 158

ISBN-13: 364248736X

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This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.

Statistics and Experimental Design for Toxicologists, Third Edition

Statistics and Experimental Design for Toxicologists, Third Edition PDF

Author: Shayne C. Gad

Publisher: CRC Press

Published: 1998-08-14

Total Pages: 456

ISBN-13: 9780849331381

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This book serves as a primary text for students of pharmacology, toxicology, and biology, and as a practical handbook to support the daily operations of the toxicology laboratory and researcher. This edition retains the structure of earlier editions, but has been extensively revised to provide both the student and the working toxicologist with the necessary tools for the rigorous and critical design of studies and analysis of experimental data. Assuming only basic mathematical skills as a starting point, Statistics and Experimental Design for Toxicologists provides a thorough and exhaustive introduction to the statistical methods available to and used in the discipline. A worked, practical example from the field is provided for each technique presented. Written from a toxicologist's perspective, this book provides both the methodological tools necessary to analyze experimental toxicology data and the insight to know when to use them.

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