Applied Statistics in the Pharmaceutical Industry

Applied Statistics in the Pharmaceutical Industry PDF

Author: Steven P. Millard

Publisher: Springer Science & Business Media

Published: 2013-11-09

Total Pages: 518

ISBN-13: 1475734662

DOWNLOAD EBOOK →

Providing a general guide to statistical methods used in the pharmaceutical industry, and illustrating how to use S-PLUS to implement these methods, the book explains why S-PLUS is a useful software package and discusses the results and implications of each particular application. It is targeted at graduates in biostatistics, statisticians involved in the industry as research scientists, regulators, academics, and/or consultants who want to know more about how to use S-PLUS and learn about other sub-fields within the industry, as well as statisticians in other fields who want to know more about statistical applications in the pharmaceutical industry.

Analyzing Medical Data Using S-PLUS

Analyzing Medical Data Using S-PLUS PDF

Author: Brian Everitt

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 488

ISBN-13: 1475732856

DOWNLOAD EBOOK →

Each chapter consists of basic statistical theory, simple examples of S-PLUS code, plus more complex examples of S-PLUS code, and exercises. All data sets are taken from genuine medical investigations and will be available on a web site. The examples in the book contain extensive graphical analysis to highlight one of the prime features of S-PLUS. Written with few details of S-PLUS and less technical descriptions, the book concentrates solely on medical data sets, demonstrating the flexibility of S-PLUS and its huge advantages, particularly for applied medical statisticians.

Regression Modeling Strategies

Regression Modeling Strategies PDF

Author: Frank E. Harrell

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 583

ISBN-13: 147573462X

DOWNLOAD EBOOK →

Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".

Statistical Methods in Drug Combination Studies

Statistical Methods in Drug Combination Studies PDF

Author: Wei Zhao

Publisher: CRC Press

Published: 2014-12-19

Total Pages: 236

ISBN-13: 1482216752

DOWNLOAD EBOOK →

The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. Howeve

The Basics of S-PLUS

The Basics of S-PLUS PDF

Author: Andreas Krause

Publisher: Springer Science & Business Media

Published: 2007-11-24

Total Pages: 432

ISBN-13: 0387227083

DOWNLOAD EBOOK →

In a clear style the most important ideas of S-PLUS are introduced through the use of many examples. Each chapter includes a collection of exercises, fully worked-out solutions and detailed comments.

Pharmacometrics

Pharmacometrics PDF

Author: Ene I. Ette

Publisher: John Wiley & Sons

Published: 2013-03-14

Total Pages: 1236

ISBN-13: 1118679512

DOWNLOAD EBOOK →

Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: Integrates theory and practice to let the reader apply principles and concepts. Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

Design and Analysis of Cross-Over Trials, Second Edition

Design and Analysis of Cross-Over Trials, Second Edition PDF

Author: Byron Jones

Publisher: CRC Press

Published: 2003-03-12

Total Pages: 390

ISBN-13: 1420036092

DOWNLOAD EBOOK →

The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include: A new chapter on bioequivalence Recently developed methods for analyzing longitudinal continuous and categorical data Real-world examples using the SAS system A comprehensive catalog of designs, datasets, and SAS programs available on a companion Web site at www.crcpress.com The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come.

Design and Analysis of Cross-Over Trials

Design and Analysis of Cross-Over Trials PDF

Author: Byron Jones

Publisher: CRC Press

Published: 2014-10-08

Total Pages: 431

ISBN-13: 1439861439

DOWNLOAD EBOOK →

Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture.T

Lanterna Rally - Theme by Grace Themes