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Applied Epigenomic Epidemiology Essentials

Author: Jr. Holmes, Laurens (Nemours Healthcare System Wilmington Delaware USA)

Publisher: Routledge

Published: 2023-12

Total Pages: 0

ISBN-13: 9780367556273

This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate emerging research on epigenomics into practice. Epidemiology has a vital strategic role in facilitating and leading evidence discovery in all aspects of human health, with the intent of improving patient and public health through disease control and health promotion practices. Emphasizing what we now know about the transformation the human body and the ecosystem undergo as a result of social structure, environment, daily challenges, and mutation. The first part of this text explores the origin of epidemiology, its relationship with medicine and public health, and its role in assessing disease distribution as occurrence or frequency, risk factors, treatment and management. The main direction of this text explores the assessment of how the gene and environment interaction, termed epigenomic modulations as aberrant predispose to morbidity, prognosis, survival and mortality at individual as well as the specific population level. This text presents a novel approach mainly epigenomic modulations in the application epidemiologic investigation in disease incidence, morbidity, and mortality at specific population level for graduate education in public health and clinical sciences as well as medical education.

Applied Epigenomic Epidemiology Essentials

Author: Laurens Holmes, Jr.

Publisher: Taylor & Francis

Published: 2023-12-01

Total Pages: 332

ISBN-13: 1003816452

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This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate emerging research on epigenomics into practice. Epidemiology has a vital strategic role in facilitating and leading evidence discovery in all aspects of human health, with the intent of improving patient and public health through disease control and health promotion practices. It emphasizes what we now know about the transformation the human body and the ecosystem undergo as a result of social structure, environment, daily challenges and mutation. The first part of this text explores the origin of epidemiology, its relationship with medicine and public health, and its role in assessing disease distribution as occurrence or frequency, risk factors, treatment and management. The main direction of this text is to explore the assessment of how gene and environment interactions, termed epigenomic modulations, aberrantly predispose to morbidity, prognosis, survival and mortality at the individual as well as the specific population level. This text presents a novel approach based mainly on epigenomic modulations in the application of epidemiologic investigation in disease incidence, morbidity and mortality at a specific population level for graduate education in public health and clinical sciences as well as medical education.

Epigenetic Epidemiology

Author: Karin B. Michels

Publisher: Springer Science & Business Media

Published: 2012-01-03

Total Pages: 450

ISBN-13: 9400724942

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The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Principles of Genetics and Molecular Epidemiology

Author: Juan Carlos Gomez-Verjan

Publisher: Springer Nature

Published: 2022-01-28

Total Pages: 214

ISBN-13: 3030896013

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This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice.

Molecular Epidemiology

Author: Paul A. Schulte

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 609

ISBN-13: 0323138578

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This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Molecular Tools and Infectious Disease Epidemiology

Author: Betsy Foxman

Publisher: Academic Press

Published: 2010-12-28

Total Pages: 228

ISBN-13: 0080920845

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Molecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies. Presents the key points of consideration when integrating molecular biology and epidemiology Discusses how using molecular tools in epidemiologic research affects program design and conduct Considers the ethical concerns that arise in molecular epidemiologic studies Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field

DNA Methylation and Complex Human Disease

Author: Michel Neidhart

Publisher: Academic Press

Published: 2015-08-11

Total Pages: 546

ISBN-13: 0127999205

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DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Epigenetic Epidemiology

Author: Karin B. Michels

Publisher: Springer Nature

Published: 2022-04-14

Total Pages: 516

ISBN-13: 3030944751

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Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation. Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizes the latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders. Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.

Environmental Epigenetics

Author: L. Joseph Su

Publisher: Springer

Published: 2015-05-18

Total Pages: 327

ISBN-13: 1447166787

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This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Applied Epidemiologic Principles and Concepts

Author: Laurens Holmes, Jr.

Publisher: CRC Press

Published: 2017-12-14

Total Pages: 316

ISBN-13: 1498733832

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This book provides practical knowledge to clinicians and biomedical researchers using biological and biochemical specimen/samples in order to understand health and disease processes at cellular, clinical, and population levels. Concepts and techniques provided will help researchers design and conduct studies, then translate data from bench to clinics in attempt to improve the health of patients and populations. This book presents the extreme complexity of epidemiologic research in a concise manner that will address the issue of confounders, thus allowing for more valid inferences and yielding results that are more reliable and accurate.