AOSpine Masters Series, Volume 7: Spinal Cord Injury and Regeneration

AOSpine Masters Series, Volume 7: Spinal Cord Injury and Regeneration PDF

Author: Michael G. Fehlings

Publisher: Thieme

Published: 2016-09-15

Total Pages: 291

ISBN-13: 1638531579

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World-renowned experts share the latest updates in translational research as well as surgical and nonsurgical strategies for treating spinal cord injury Spinal cord injury (SCI) is a devastating, clinically challenging injury, leading to varying degrees of neurological function impairment and paralysis. Underlying biological mechanisms either inhibit or promote new growth in the spinal cord. Researchers have been making important discoveries about how neurons and their axons grow in the central nervous system and why they fail to regenerate after SCI. Although progress has been steady, there remains an urgent need to address issues in acute management such as early decompression and the use of biologics, as well as potential solutions for regeneration. Written by renowned experts in the ever-evolving field of SCI research and clinical practice, the 7th volume in the AOSpine Masters series is a state-of-the-art compendium on the latest in SCI diagnosis, spine surgery interventions, and long-term management. Each chapter contains pearls from leading spine specialists gleaned from the research laboratory and years of hands-on experience treating SCI patients in the emergency setting and long term. Key Features: Pathobiology, assessment, and diagnostic considerations The use of biomarkers as predictors of functional recovery Surgical and nonsurgical interventions for traumatic SCI The role of neural stem cells and biologics in spinal cord repair Functional and epidural stimulation and brain-computer interfaces The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This essential textbook delivers invaluable insights to spine surgeons, spinal cord injury clinicians and researchers and trainees, from translational researchers to experienced researchers and clinicians experienced in the operative and non-operative management of spinal cord injury.

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma PDF

Author: Michael Fehlings

Publisher: Academic Press

Published: 2022-02-17

Total Pages: 646

ISBN-13: 0128198362

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Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

Spinal Cord Injury and Regeneration

Spinal Cord Injury and Regeneration PDF

Author: Luiz Roberto Vialle

Publisher: Thieme Medical Publishers

Published: 2016-10-07

Total Pages: 216

ISBN-13: 9781626232273

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World-renowned experts share the latest updates in translational research as well as surgical and nonsurgical strategies for treating spinal cord injury Spinal cord injury (SCI) is a devastating, clinically challenging injury, leading to varying degrees of neurological function impairment and paralysis. Underlying biological mechanisms either inhibit or promote new growth in the spinal cord. Researchers have been making important discoveries about how neurons and their axons grow in the central nervous system and why they fail to regenerate after SCI. Although progress has been steady, there remains an urgent need to address issues in acute management such as early decompression and the use of biologics, as well as potential solutions for regeneration. Written by renowned experts in the ever-evolving field of SCI research and clinical practice, the 7th volume in the AOSpine Masters series is a state-of-the-art compendium on the latest in SCI diagnosis, spine surgery interventions, and long-term management. Each chapter contains pearls from leading spine specialists gleaned from the research laboratory and years of hands-on experience treating SCI patients in the emergency setting and long term. Key Features: Pathobiology, assessment, and diagnostic considerations The use of biomarkers as predictors of functional recovery Surgical and nonsurgical interventions for traumatic SCI The role of neural stem cells and biologics in spinal cord repair Functional and epidural stimulation and brain-computer interfaces The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This essential textbook delivers invaluable insights to spine surgeons, spinal cord injury clinicians and researchers and trainees, from translational researchers to experienced researchers and clinicians experienced in the operative and non-operative management of spinal cord injury.

AOSpine Masters Series, Volume 5: Cervical Spine Trauma

AOSpine Masters Series, Volume 5: Cervical Spine Trauma PDF

Author: Luiz Roberto Gomes Vialle

Publisher: Thieme

Published: 2015-07-30

Total Pages: 298

ISBN-13: 1626232245

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This fifth volume in the AOSpine Masters Series presents a detailed analysis of the essential aspects of managing the most common cervical spine injuries. World-renowned cervical spine experts discuss anatomy, biomechanics, patient evaluation, and critical steps in the decision-making process for the treatment of these complex injuries. Chapters include: Anatomy of the Cervical Spine, Nonoperative Management of Cervical Spine Trauma, and Subaxial Cervical Spine Injuries. Key Features: Each chapter provides historic literature as well as a synthesized analysis of current literature and proposes an evidence-based treatment plan Editors are international authorities on the management of cervical spine injuries Expert tips and pearls included in every chapter The AOSpine Masters Series, a copublication of Thieme and AOSpine, a Clinical Division of the AO Foundation, addresses current clinical issues whereby international masters of spine share their expertise and recommendations on a particular topic. The goal of the series is to contribute to an evolving, dynamic model of an evidence-based medicine approach to spine care. All spine surgeons, orthopaedic surgeons, and neurosurgeons, along with residents and fellows in these areas, will find this book to be an excellent reference that they will consult often in their treatment of patients with cervical spine injuries.

AOSpine Masters Series, Volume 8: Back Pain

AOSpine Masters Series, Volume 8: Back Pain PDF

Author: Jeffrey Wang

Publisher: Thieme

Published: 2016-12-01

Total Pages: 322

ISBN-13: 1638531587

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Current statistics indicate that 75-80% of people worldwide will experience some form of back pain during their lifetime. Lumbar pain is a leading cause of disability - a global public health burden with serious economic implications. Written by internationally renowned spine experts, the 8th volume in the AOSpine Masters series is a concise, state-of-the-art overview on fundamental management strategies and current issues and challenges. The text covers the full age spectrum - from childhood to older adulthood - and contributing factors such as the sacroiliac joints, genetics, and spine infections. Clinical evaluation, treatment options, recent research advances, and future perspectives are systematically examined and presented in a clear format. With commentary from leading authorities, this compendium presents candid discussion of significant challenges faced by clinicians who treat back pain. Among the issues addressed are managing patients who have undergone multiple operations, chronic back pain, failed spine surgery, and what to do when all nonsurgical and surgical options have been exhausted. Key Highlights Economic considerations, risk factors, and legal aspects Neurological causes, including myopathies, neuromuscular disease, Parkinson disease,and dystonia Conservative treatment options such as drugs, physiotherapy, and complementary medicine The role of minimally invasive surgery in treating degenerative lumbar spine disease Must-read bibliographic references in every chapter Bullet lists of pearls and pitfalls summarize critical points and key concepts The AOSpine Masters series, a co-publication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care.

AOSpine Masters Series, Volume 9: Pediatric Spinal Deformities

AOSpine Masters Series, Volume 9: Pediatric Spinal Deformities PDF

Author: Marinus de Kleuver

Publisher: Thieme

Published: 2017-09-01

Total Pages: 354

ISBN-13: 162623454X

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An estimated 9 million children every year are affected by pediatric spinal deformities, encompassing a broad spectrum of pathologies. New classification systems, innovative imaging modalities, and advances in surgical techniques have contributed to a continually evolving, evidence-based treatment paradigm. Patient variables such as the age of onset, severity, course of deformity progression, as well as the availability of technology pose individualized challenges. AOSpine Masters Series, Volume 9: Pediatric Spinal Deformity is a concise yet comprehensive review of fundamental surgical and nonsurgical approaches, contemporary issues, and treatment obstacles. Internationally renowned spine surgeons Luis Roberto Vialle, Marinus de Kleuver, and Sigurd Berven and a cadre of esteemed contributors deliver a state-of-the-art reference on deformities of the pediatric spine. From early childhood to adolescent spine disorders, 17 richly illustrated chapters cover diagnosis, preoperative evaluation, imaging, spine surgery interventions, non-fusion procedures, and long-term management. Key Highlights Overviews on the classification and natural history of early onset scoliosis and adolescent idiopathic scoliosis, with subsequent chapters covering non-operative management and contemporary surgical techniques Evidence-based discussion of long-term surgical care outcomes, indications for revision surgery, and strategies for achieving optimal results Management of congenital and developmental kyphosis, lordosis, syndromic conditions, and low and high grade spondylolisthesis Clinical pearls on spine surgery in the developing world, safety issues and complications, and the importance of developing outcome metrics The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This outstanding textbook is a must have for spine surgeons, in particular those who specialize in treating childhood spine disorders. Orthopaedic and neurosurgery residents, as well as veteran surgeons with extensive knowledge will find this an indispensable tool for daily practice.

AOSpine Masters Series, Volume 10: Spinal Infections

AOSpine Masters Series, Volume 10: Spinal Infections PDF

Author: S. Rajasekaran

Publisher: Thieme

Published: 2018-06-15

Total Pages: 202

ISBN-13: 1626234566

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Renowned spine experts share recent advances on the management of spinal infections AOSpine Masters Series, Volume 10: Spinal Infections is a concise, state-of-the-art review covering all aspects of spinal infections – from basic science and epidemiology to fundamental surgical and nonsurgical approaches. Internationally renowned spine surgeons Luis Roberto Vialle, S. Rajasekaran, Rishi Kanna, Giuseppe Barbagallo, and many experts across the world, provide clinical pearls and insights gleaned from years of hands-on expertise. This book provides discussion of underlying pathologies, imaging and diagnosis, and surgical techniques, with a focus on issues specific to children, co-infection with HIV, postoperative problems, geriatric patients, and pseudoarthrosis. Key Highlights Overviews on the epidemiology, microbiology, and pathology of spinal infections Detailed review of imaging, and other investigations Treatment planning and surgical techniques Risk stratification and prevention of post-operative infection Pathogenesis, clinical features, diagnosis, and treatment of pyogenic spondylodiscitis in various regions of the spine Clinical pearls on the management of spinal tuberculosis, including drug therapy and surgery The AOSpine Masters series, a co-publication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evidence-based approach to spine care. This textbook is essential reading for all spine surgeons. Orthopaedic and neurosurgery residents, as well as veteran surgeons will find this a useful tool for daily practice.

Intervertebral Disc Regeneration

Intervertebral Disc Regeneration PDF

Author: Benjamin Gantenbein

Publisher: Mdpi AG

Published: 2022-01-11

Total Pages: 138

ISBN-13: 9783036527543

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This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.

Diseases of the Brain, Head and Neck, Spine 2020–2023

Diseases of the Brain, Head and Neck, Spine 2020–2023 PDF

Author: Juerg Hodler

Publisher: Springer Nature

Published: 2020-02-14

Total Pages: 252

ISBN-13: 303038490X

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This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

The Physiology of Exercise in Spinal Cord Injury

The Physiology of Exercise in Spinal Cord Injury PDF

Author: J. Andrew Taylor

Publisher: Springer

Published: 2016-12-20

Total Pages: 286

ISBN-13: 1493966642

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Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury (SCI). Those with an SCI are two to five times more likely to die prematurely than people without a spinal cord injury, with worse survival rates in low- and middle-income countries. Dynamic aerobic requires integrated physiologic responses across the musculoskeletal, cardiovascular, autonomic, pulmonary, thermoregulatory, and immunologic systems. Moreover, regular aerobic exercise beneficially impacts these same systems, reducing the risk for a range of diseases and maladies. This book will present comprehensive information on the unique physiologic effects of SCI and the potential role of exercise in treating and mitigating these effects. In addition, it will incorporate work from scientists across a number of disciplines and have contributors at multiple levels of investigation and across physiologic systems. Furthermore, SCI can be considered an accelerated form of aging due to the severely restricted physical inactivity imposed, usually at an early age. Therefore, the information presented may have a broader importance to the physiology of aging as it relates to inactivity. Lastly, the need for certain levels of regular aerobic exercise to engender adaptations beneficial to health is not altered by the burden of an SCI. Indeed, the amounts of exercise necessary may be even greater than the able-bodied due to ‘passive’ ambulation. This book will also address the potential health benefits for those with an SCI that can be realized if a sufficient exercise stimulus is provided.