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Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Author:

Publisher: Academic Press

Published: 2022-01-14

Total Pages: 296

ISBN-13: 0323905560

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

Antiangiogenic Cancer Therapy

Author: Darren W. Davis

Publisher: CRC Press

Published: 2007-07-25

Total Pages: 878

ISBN-13: 1420004298

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Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bev

Antiangiogenic Agents in Cancer Therapy

Author: Beverly A. Teicher

Publisher: Springer Science & Business Media

Published: 2008-01-08

Total Pages: 585

ISBN-13: 1597451843

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This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

Antiangiogenic Agents in Cancer Therapy

Author: Beverly A. Teicher

Publisher:

Published: 2014-01-15

Total Pages: 470

ISBN-13: 9781475745177

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Cancer Cell Chemoresistance and Chemosensitization

Author: Ajaikumar B. Kunnumakkara

Publisher: World Scientific

Published: 2018

Total Pages: 682

ISBN-13: 9813208570

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Introduction and basic concepts of cancer / Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nafiseh Mantegh, Ganesan Padmavathi, Ajaikumar B. Kunnumakkara -- Cancer cell chemoresistance : a prime obstacle in cancer therapy -- Javadi Monisha [and 6 others] -- Bladder cancer : chemoresistance and chemosensitization / Nand Kishor Roy, Anand Sharma, Anuj Kumar Singh, Devivasha Bordoloi, Ajaikumar B. Kunnumakkara -- Mechanism of chemoresistance in bone cancer and different chemosensitization approaches / Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik, Anuj Kumar Singh, Ajaikumar B. Kunnumakkara -- Chemoresistance in brain cancer and different chemosensitization approaches / Amrita Devi Khwairakpam [and 6 others] -- Phytochemicals as chemosensitizers in breast cancer / Madhumita Roy, Ruma Sarkar, Apurba Mukherjee, Sutapa Mukherjee & Jaydip Biswas -- Potential of different chemosensitizers to overcome chemoresistance in cervical cancer / Kishore Banik [and 5 others] -- Colon cancer chemoresistance and chemosensitization / Muthu K. Shanmugam, Arunasalam Dharmarajan, Frank Arfuso, Gautam Sethi -- Cancer cell chemoresistance and chemosensitization in endometrial cancer / Anuj Kumar Singh [and 5 others] -- Different approaches to overcome chemoresistance in esophageal cancer / Devivasha Bordoloi [and 5 others] -- Different chemosensitization approaches in gastric cancer / Choudhary Harsha [and 5 others] -- Chemoresistance and chemosensitization in haematological malignancies / Ota Fuchs -- Different methods to inhibit chemosresistance in hepatocellular carcinoma / Anuj Kumar Singh [and 6 others] -- Different chemosensitization approaches for the effective management of HNSCC / Krishan K. Thakur, Devivasha Bordoloi, Jai Prakash, Nand Kishor Roy, Ajaikumar B. Kunnumakkara -- Lung cancer chemoresistance and chemosensitization / Kenneth K.W. To -- Sensitization of chemoresistant melanoma cells to different chemotherapeutic agents / Javadi Monisha [and 5 others] -- Strategies to overcome chemoresistance in ovarian cancer / Choudhary Harsha [and 5 others] -- Molecular alterations involved in pancreatic cancer chemoresistance and chemosensitization strategies / Bethsebie Lalduhsaki Sailo [and 8 others] -- Different chemosensitization approaches to overcome chemoresistance in prostate cancer / Ganesan Padmavathi [and 6 others] -- Therapeutic strategies for chemosensitization of renal cancer / Bethsebie Lalduhsaki Sailo, Devivasha Bordoloi, Kishore Banik, Jai Prakash, Ajaikumar B. Kunnumakkara.

Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

Author: Benjamin Bonavida

Publisher: Springer Science & Business Media

Published: 2008-07-31

Total Pages: 431

ISBN-13: 1597454745

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This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.

Anti-Angiogenesis Strategies in Cancer Therapies

Author: Shaker Mousa

Publisher: Academic Press

Published: 2016-11-28

Total Pages: 210

ISBN-13: 0128026731

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Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Anti-Angiogenesis Drug Discovery and Development: Volume 5

Author: Atta-ur-Rahman

Publisher: Bentham Science Publishers

Published: 2020-10-05

Total Pages: 212

ISBN-13: 9811432864

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The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents

Medicinal Chemistry of Anticancer Drugs

Author: Carmen Avendaño

Publisher: Elsevier

Published: 2015-06-11

Total Pages: 767

ISBN-13: 0444626670

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Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Role of Nutraceuticals in Cancer Chemosensitization

Author:

Publisher: Academic Press

Published: 2017-10-18

Total Pages: 398

ISBN-13: 0128123745

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Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations