Animals Viruses and Humans, A Narrow Divide

Animals Viruses and Humans, A Narrow Divide PDF

Author: Warren A. Andiman

Publisher: Paul Dry Books

Published: 2018-05-24

Total Pages: 217

ISBN-13: 1589881222

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"A frighteningly fascinating reminder of just how closely connected human health and the planet’s ecosystems are."—Booklist "Andiman gives you a front row seat in the ongoing battle between man and disease . . . Gripping stories, filled with details that are in equal part delicious and disgusting, but always fascinating."—Lisa Sanders, MD, author of Every Patient Tells a Story and the New York Times Magazine "Diagnosis" column "Dr. Andiman was at the forefront of the HIV/AIDS epidemic in America, so he knows as well as anyone the disrupting power of new viruses and their impact on human societies."—Peter Hotez, MD, PhD, Dean, National School of Tropical Medicine at Baylor College of Medicine “To reproduce promiscuously and to wreak havoc wherever they can find a home,” this is the raison d’être of viruses, writes Dr. Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious diseases for over forty years. In Animal Viruses and Humans: A Narrow Divide, Andiman traces the history of eight zoonotic viruses—deadly microbes that have made the leap directly from animals to human populations: Middle East Respiratory Syndrome (MERS) * Swine influenza * Hantavirus * Monkeypox * Severe Acute Respiratory Syndrome (SARS) * Rabies * Ebola * Henipaviruses (Nipah and Hendra). He also illustrates the labor intensive and fascinating detective work that infectious disease specialists must do to uncover the source of an outbreak. Andiman also looks to the future, envisioning the effects on zoonoses (diseases caused by zoonotic viruses) of climate change, microenvironmental damage, population shifts, and globalization. He reveals the steps that we can, and must, take to stem the spread of animal viruses, explaining, “The zoonoses I've chosen to write about . . . are meant to describe only a small sample of what is already out there but, more menacingly, what is inevitably on its way, in forms we can only imagine.”

Animal Viruses and Humans, a Narrow Divide

Animal Viruses and Humans, a Narrow Divide PDF

Author: Warren A. Andiman

Publisher:

Published: 2018

Total Pages:

ISBN-13: 9781589883307

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"Dr. Andiman was at the forefront of the HIV/AIDS epidemic in America, so he knows as well as anyone the disrupting power of new viruses and their impact on human societies."--Peter Hotez, MD, PhD, Dean, National School of Tropical Medicine at Baylor College of Medicine "To reproduce promiscuously and to wreak havoc wherever they can find a home," this is the sole raison d'être of viruses writes Dr. Warren Andiman, an HIV/AIDS researcher who has been on the front lines battling infectious diseases for over forty years. In Animal Viruses and Humans, A Narrow Divide, Dr. Andiman introduces readers to the ominous world of zoonotic viruses, those deadly microbes that sometimes spread directly from animals to humans. Andiman traces the history of eight deadly zoonoses as they make the leap to human populations: Middle East Respiratory Syndrome (MERS), Swine influenza, Hantavirus, Monkeypox, Severe Acute Respiratory Syndrome (SARS), Rabies, Ebola, and Henipaviruses (Nipah and Hendra). Through these examples he describes the fundamental characteristics of zoonotic viruses: what they look like, where they come from, how they invade so efficiently, and when and why they infect human populations. He also illustrates the labor intensive and fascinating detective work that infectious disease specialists must do to uncover the source of an outbreak. In these essays, Andiman looks to the future, making reference to the worrisome effects on zoonoses of climate change, microenvironmental damage, population shifts, and globalization. He describes some current trends in vaccine and antiviral drug development, and introduces organizations like the European Center for Disease Prevention and Control, the EcoHealth Alliance, and the National Academy of Medicine Commission on Global Risk Framework for the Future, all of which are tasked with anticipating future zoonoses. Andiman reveals the most important steps that we can, and must, take to stem the spread of animal viruses, explaining, "The zoonoses I've chosen to write about . . . are meant to describe only a small sample of what is already out there but, more menacingly, what is inevitably on its way, in forms we can only imagine." Dr. Warren Andiman is Professor emeritus of pediatrics and epidemiology at the Yale Schools of Medicine and Public Health. He received his medical degree from Albert Einstein College of Medicine in New York and completed his pediatric residency at Babies Hospital, part of the former Columbia-Presbyterian Medical Center. After serving a two-year stint as a Captain in the U.S. Army Medical Corps, he pursued a post-doctoral fellowship in pediatric infectious diseases at the Yale School of Medicine and joined the faculty on which he served for forty-two years. At the start of the AIDS epidemic Dr. Andiman, with his associates, created the Pediatric AIDS Care Program at Yale-New Haven Hospital and served as its medical director for thirty-two years. He lives in Connecticut with his wife, also a pediatrician. They have two daughters.

Spillover: Animal Infections and the Next Human Pandemic

Spillover: Animal Infections and the Next Human Pandemic PDF

Author: David Quammen

Publisher: W. W. Norton & Company

Published: 2012-10-01

Total Pages: 592

ISBN-13: 0393239225

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"[Mr. Quammen] is not just among our best science writers but among our best writers, period." —Dwight Garner, New York Times The next big human pandemic—the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza—is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event “spillover” and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops of Bangladesh, and the caves of southern China to the laboratories where researchers work in space suits to study lethal viruses. He illuminates the dynamics of Ebola, SARS, bird flu, Lyme disease, and other emerging threats and tells the story of AIDS and its origins as it has never before been told. Spillover reads like a mystery tale, full of mayhem and clues and questions. When the Next Big One arrives, what will it look like? From which innocent host animal will it emerge? Will we be ready?

When Germs Travel

When Germs Travel PDF

Author: Howard Markel

Publisher: Vintage

Published: 2009-01-21

Total Pages: 290

ISBN-13: 0307493075

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The struggle against deadly microbes is endless. Diseases that have plagued human beings since ancient times still exist, new maladies make their way into the headlines, we are faced with vaccine shortages, and the threat of germ warfare has reemerged as a worldwide threat. In this riveting account, medical historian Howard Markel takes an eye-opening look at the fragility of the American public health system. He tells the distinctive stories of six epidemics–tuberculosis, bubonic plague, trachoma, typhus, cholera, and AIDS–to show how our chief defense against diseases from outside the United States has been to attempt to deny entry to carriers. He explains why this approach never worked, and makes clear that it is useless in today’s world of bustling international travel and porous borders. Illuminating our foolhardy attempts at isolation and showing that globalization renders us all potential inhabitants of the so-called Hot Zone, Markel makes a compelling case for a globally funded public health program that could stop the spread of epidemics and safeguard the health of everyone on the planet.

Molecular Virology of Human Pathogenic Viruses

Molecular Virology of Human Pathogenic Viruses PDF

Author: Wang-Shick Ryu

Publisher: Academic Press

Published: 2016-03-30

Total Pages: 441

ISBN-13: 0128009993

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Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank

Viruses

Viruses PDF

Author: Paula Tennant

Publisher: Academic Press

Published: 2018-03-12

Total Pages: 392

ISBN-13: 0128111941

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Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived ‘interactomics’ as defined by the molecules and the processes by which virus gene products interact with themselves and their host’s cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses Provides key insights into recent technological advances, including high-throughput sequencing Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions

Assessment of Future Scientific Needs for Live Variola Virus

Assessment of Future Scientific Needs for Live Variola Virus PDF

Author: Committee on the Assessment of Future Scientific Needs for Variola Virus

Publisher: National Academies Press

Published: 1999-05-14

Total Pages: 126

ISBN-13: 030959698X

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In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research PDF

Author: P. Michael Conn

Publisher: Springer Science & Business Media

Published: 2008

Total Pages: 756

ISBN-13: 1588299333

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The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.