The Mechanism of Action of Androgens

The Mechanism of Action of Androgens PDF

Author: W.I.P. Mainwaring

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 184

ISBN-13: 3642884296

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My introduction to androgens was neither auspicious nor impressive. I was sitting my viva voce examination for a degree in physiology and had haltingly intimated to my examiner (name decorously withheld) that I intended to pursue a career in re search. "On what topic?" was the reply. I had been deeply impressed by the work of C. Huggins and C. V. Hodges (Cancer Res. 1, 293, 1941) on the dramatic arrest of canine prostatic hyperplasia by the administration of stilboestrol. With some en thusiasm, I responded, "On steroid hormones, because I am struck by the profound effects that may be achieved by relatively small numbers of molecules. " The examiner sank into deep contemplation before replying, "Young man, have you considered go ing into teaching?" Suitably chastened, I finally began my research career investigating the effects of steroids on the nucleic acid metabolism of experimental tumours and on the process cells. Reaching an impasse in this work, I mentioned one of senescence in animal day to Dr. G. F. Marrian that, somewhat surprisingly, we had no understanding of the fundamental mechanism of action of steroid hormones, especially the androgens. me to tackle this problem, particularly since exciting new insights He encouraged were then being made into the interaction of radioactively labelled oestradiol-l?,8 with such tissues as rat uterus.

Androgens and Androgen Receptor

Androgens and Androgen Receptor PDF

Author: Chawnshang Chang

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 507

ISBN-13: 1461511615

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Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications. Key topics covered include: -The discovery and cloning of the androgen receptor; -Androgen receptor coregulators; -Androgen related genes and their consensus DNA response elements; -Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies; -Cross-talk to other signal transduction systems; -The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer. This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

Hyperandrogenism in Women

Hyperandrogenism in Women PDF

Author: R. Pasquali

Publisher: Karger Medical and Scientific Publishers

Published: 2019-09-09

Total Pages: 201

ISBN-13: 3318064718

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Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions.

Androgen Action in Prostate Cancer

Androgen Action in Prostate Cancer PDF

Author: Donald Tindall

Publisher: Springer Science & Business Media

Published: 2009-04-20

Total Pages: 782

ISBN-13: 0387691790

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Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included

Androgen Action

Androgen Action PDF

Author: Fahri Saatcioglu

Publisher: Humana Press

Published: 2011-08-04

Total Pages: 386

ISBN-13: 9781617792441

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Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.

Pharmacology, Biology, and Clinical Applications of Androgens

Pharmacology, Biology, and Clinical Applications of Androgens PDF

Author: Chuck Kelly

Publisher: John Wiley & Sons

Published: 1996-02-13

Total Pages: 552

ISBN-13: 9780471133209

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Pharmacology, Biology, and Clinical Applications of AndrogensCurrent Status and Future Prospects Edited by Shalender Bhasin, Henry L. Gabelnick, Jeffrey M. Spieler,Ronald S. Swerdloff, Christina Wang, and Chuck Kelly As agents that affect the male primary and accessory sex organs,androgens--particularly the hormones testosterone andandrosterone--play a critical role in the development,functionality, and overall health of the male reproductive system.However, since androgens also have far-ranging effects onmetabolism, neurological activity, and behavior, scientistsexploring the contraceptive or therapeutic potential of androgensneed reliable, up-to-date information on the complex biologicalactivities of these agents. Pharmacology, Biology, and Clinical Applications of Androgens:Current Status and Future Prospects presents contributions fromleading investigators around the world, offering a focused,state-of-the-art summary of the central issues and controversies inandrogen research. The book is arranged into sections coveringandrogen physiology, androgens and the prostate, and theneurobehavioral and metabolic effects of androgens--as well astheir role in disease therapy and male contraception, and thevarious delivery systems for each application. Every chapter in thetext provides an expert opinion on a cutting-edge topic in thefield while highlighting the key points of dissent and disagreementwithin the scientific community. This approach is intended tofoster a deeper understanding of the status of androgen researchand lay the groundwork for future investigations in eacharea. This book explores such current topics as: * Androgen regulation of Sertoli cell function * Testosterone and spermatogenesis * Androgen effects on benign prostatic hyperplasia (BPH) andprostate cancer * Androgen effects on cognitive processes, sexual function, andaggressive behavior * Contraceptive efficacy of hormonal suppression of spermatogenesis * The latest transdermal and implantation delivery systems forandrogens Offering multifaceted coverage of the field, Pharmacology, Biology,and Clinical Applications of Androgens is an indispensable aid toall basic scientists and clinical investigators interested in thebiological actions of either natural or synthetic androgens.

Androgens in Gynecological Practice

Androgens in Gynecological Practice PDF

Author: Leo Plouffe, Jr

Publisher: Cambridge University Press

Published: 2015-06-25

Total Pages: 261

ISBN-13: 1316298876

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A practical approach to the field of androgen excess or deprivation in women's health. The content includes multiple viewpoints on the most common disorders in this class, such as polycystic ovary disease, hirsutism and menopausal issues. Each chapter provides a combination of long-lasting clinical principles in the diagnosis and management of these patients along with a state-of-the-art review. This text takes an innovative approach to uncommon conditions (such as congenital adrenal hyperplasia, transgender conditions). In addition to presenting clinical insights, and a review of the basic science underpinning these conditions, it focuses on key concepts that can be derived from these rare conditions to the entire field. This book is an essential addition to the library for any busy clinician who is looking for a practical reference guide but also for the sub-specialist who is looking for new and thought-provoking insights in this complex scientific area.

Androgen Action

Androgen Action PDF

Author: Fahri Saatcioglu

Publisher: Humana Press

Published: 2011-08-09

Total Pages: 0

ISBN-13: 9781617792427

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Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.

Testosterone

Testosterone PDF

Author: Susan Nieschlag

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 296

ISBN-13: 3662008149

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New developments in testosterone therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in fourteen chapters. The book begins with the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Three chapters deal with specific aspects of testosterone action, namely its role in spermatogenesis, its psychotropic effects and its effects on bones. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. Causes and symptoms of male hypogonadism, the major indication for testosterone treatment, are described. Five chapters are devoted to the pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations. The new transdermal testosterone application is described in detail. Side effects of testosterone treatment are reviewed. The possible role of androgens in the development of prostatic hypertrophy and carcinoma is discussed extensively since this question is of major concern to the clinician.

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