Alzheimer's Disease and Infectious Causes

Alzheimer's Disease and Infectious Causes PDF

Author: Elaine A. Moore

Publisher: McFarland

Published: 2020-04-02

Total Pages: 233

ISBN-13: 1476678618

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With the recent discovery that amyloid beta protein, the cause of plaques in Alzheimer's disease, is an antimicrobial peptide produced in response to infection, many researchers are focusing on the role infection plays in the development of Alzheimer's disease. Brain studies have also identified a number of different viruses, bacteria, fungi, and protozoa in the postmortem brain specimens of Alzheimer's patients. Infection (particularly chronic, latent and persistent infections) causes an immune response that leads to inflammation and brain cell degeneration, which are characteristic features of Alzheimer's disease. Sources of infection in Alzheimer's disease vary from childhood infections to gut microbes that find their way into the brain as a result of aging, leaky gut syndrome, and increased permeability of the blood brain barrier. Studies and ongoing clinical trials show that treatment of viral and bacterial infections, as well as restoring a healthy balance to the gut microbiome, can reduce disease risk and improve symptoms in patients with Alzheimer's disease. This book serves as an introduction to the human microbiome and the role that infection plays in the development of Alzheimer's disease.

Alzheimer's Disease and Infectious Causes

Alzheimer's Disease and Infectious Causes PDF

Author: Elaine A. Moore

Publisher: McFarland

Published: 2020-04-01

Total Pages: 233

ISBN-13: 1476638918

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With the recent discovery that amyloid beta protein, the cause of plaques in Alzheimer's disease, is an antimicrobial peptide produced in response to infection, many researchers are focusing on the role infection plays in the development of Alzheimer's disease. Brain studies have also identified a number of different viruses, bacteria, fungi, and protozoa in the postmortem brain specimens of Alzheimer's patients. Infection (particularly chronic, latent and persistent infections) causes an immune response that leads to inflammation and brain cell degeneration, which are characteristic features of Alzheimer's disease. Sources of infection in Alzheimer's disease vary from childhood infections to gut microbes that find their way into the brain as a result of aging, leaky gut syndrome, and increased permeability of the blood brain barrier. Studies and ongoing clinical trials show that treatment of viral and bacterial infections, as well as restoring a healthy balance to the gut microbiome, can reduce disease risk and improve symptoms in patients with Alzheimer's disease. This book serves as an introduction to the human microbiome and the role that infection plays in the development of Alzheimer's disease.

Handbook of Infection and Alzheimer's Disease

Handbook of Infection and Alzheimer's Disease PDF

Author: J. Miklossy

Publisher: IOS Press

Published: 2017-03-10

Total Pages: 420

ISBN-13: 1614997063

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Alzheimer’s disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer’s disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century. In recent years, evidence of the microbial origin of various chronic inflammatory disorders – including several neurodegenerative, neuropsychiatric and other systemic disorders – has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer’s disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions. This handbook assembles and connects findings with regard to the infectious origin of Alzheimer’s disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer’s disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.

Alzheimer's Disease

Alzheimer's Disease PDF

Author: Thimmaiah Govindaraju

Publisher: Royal Society of Chemistry

Published: 2022-01-04

Total Pages: 695

ISBN-13: 1839162740

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Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.

Neurology in Clinical Practice

Neurology in Clinical Practice PDF

Author: Walter George Bradley

Publisher:

Published: 2004

Total Pages: 1672

ISBN-13: 9780750674690

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New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Alzheimer's Disease

Alzheimer's Disease PDF

Author: Lawrence Broxmeyer, M.D.

Publisher:

Published: 2016-08-03

Total Pages: 190

ISBN-13: 9781491287354

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View video book trailer: https://www.youtube.com/watch'v=T4IHhHhCCds KIRKUS REVIEWS: "The author is an internist and a medical researcher, and his double mastery of both the scientific minutiae and historical nuances of his subject matter is breathtaking. This is more than an account of a scientific debate-it's also an examination of the sometimes-unempirical way that such debate proceeds, as it's conducted by human beings with agendas of their own. Although it's a relatively short book-less than 200 pages of text-it is by no means a quick read. Nevertheless, readers with strong sciencebackgrounds will be impressed by the author's undeniable competence, as well as his journalistic approach to chartering the evolution of thought regarding one of our era's most challenging diseases." Every seventy-two seconds someone in America develops Alzheimer's disease (AD). And it has been said that almost everyone living long enough will eventually show evidence of Alzheimer's disease. Thus far its cause has remained elusive. Nevertheless, recently, study after study, in which scientists have injected human Alzheimer diseased brain tissue into mice and other laboratory animals that later developed the disease have left little doubt that Alzheimer's arises from an infectious process-the focus of debate seeming to be which particular disease. And clearly, whatever the infectious cause behind Alzheimer's is, it must be a disease that is not only statistically widespread in the world today, but that was also prevalent at the time of Dr. Alzheimer. To be sure, it was German neuropathologist Oskar Fischer of the Prague school of neuropathology, Alzheimer's great rival, who was the first to suggest that infection might be causative for Alzheimer's. Fischer's credentials: he was the co-discoverer of Alzheimer's disease and tirelessly did autopsies on the brains of patients with Alzheimer's. Fischer's infectious view never gained immediate popularity, although today, more than a century later, a volume of data supporting such an approach has begun to accumulate. But was Fischer's specific microbe on the right track to discovering the cause of Alzheimer's to begin with? The evidence uncovered in this book seems to suggest that he was considerably closer than anyone else-either then or since. Now, internal medicine doctor and researcher Lawrence Broxmeyer, MD, takes readers on a journey back to the time of Dr. Alzheimer and his peers. Well-researched and documented, this important work explores a plausible, but overlooked, hypothesis about the etiology of this debilitating and widespread condition-and brings new information to the discussion about how to prevent a disease affecting millions of Americans today. So let us review that evidence.

The Origin of Disease

The Origin of Disease PDF

Author: Carolyn Merchant JD

Publisher: AuthorHouse

Published: 2018-10-12

Total Pages: 623

ISBN-13: 1546259791

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US REVIEW OF BOOKS, Michael Radon theusreview.com/reviews/The-Origin-of-Disease-by-Carolyn-Merchant-JD-and-Christopher-Merchant-MD.html#.XLBmAehKi5o Containing exciting information and thought, this book could help people find ways to improve or avoid diseases that can dramatically alter lives. This book challenges a lot of accepted thinking in Western medicine, but all truly impactful ideas have to shatter the old to move [thought] forward. [T]he authors identify a pattern of the root causes of chronic illnesses and what can be done to fight maladies that many medical professionals say just happen and have to be lived with. For many people, medical books can be a hard hurdle to jump, but this book is written in an accessible style and format, and contains information useful to the layperson, not just medical professionals. PACIFIC BOOK REVIEW. Anthony Avina pacificbookreview.com/the-origin-of-disease-the-war-within This book does a great job of creating a conversation. It is a detailed, knowledgeable and thorough book filled with fascinating theories that all readers should have the opportunity to explore themselves. This is definitely an interesting book that will fascinate patients suffering from illnesses as well as doctors seeking new answers or medical researchers alike. It is a new perspective that is interesting to see, as the authors relay the causes of various chronic illnesses. The authors command over the medical expertise is both technical and yet relayed easily enough for patients and doctors alike to understand. If you enjoy medical books, suffer from an ailment or are curious about health overall, then you’ll want to grab your copy of The Origin of Disease: The War Within, Today! www.facebook.com/carolyn.merchant/39 www.theoriginofdiseases.com

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System PDF

Author: Robert Vink

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 354

ISBN-13: 0987073052

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The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Viruses: Essential Agents of Life

Viruses: Essential Agents of Life PDF

Author: Günther Witzany

Publisher: Springer Science & Business Media

Published: 2012-11-13

Total Pages: 432

ISBN-13: 940074899X

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A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.