Aging of Cells in and Outside the Body

Aging of Cells in and Outside the Body PDF

Author: S. Kaul

Publisher: Springer Science & Business Media

Published: 2013-03-14

Total Pages: 276

ISBN-13: 9401706697

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This book provides updated knowledge on the basic features and mechanisms of cellular aging established since its first manifestation at cellular level 40 years ago. Contributions of genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications determine the final lifespan of cells. This book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumor surveillance because of stringent controls on aging mechanisms. It also appraises the use of modern technology for aging studies and its intervention. This book serves as an excellent reading on cellular aging for undergraduate students, researchers and experts of this area.

The Immortal Life of Henrietta Lacks

The Immortal Life of Henrietta Lacks PDF

Author: Rebecca Skloot

Publisher: Crown

Published: 2010-02-02

Total Pages: 386

ISBN-13: 0307589382

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#1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

Cells and Surveys

Cells and Surveys PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2001-01-19

Total Pages: 388

ISBN-13: 0309171431

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What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.

Your Body

Your Body PDF

Author: Matthew MacDonald

Publisher: "O'Reilly Media, Inc."

Published: 2009-07-21

Total Pages: 305

ISBN-13: 1449392016

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What, exactly, do you know about your body? Do you know how your immune system works? Or what your pancreas does? Or the myriad -- and often simple -- ways you can improve the way your body functions? This full-color, visually rich guide answers these questions and more. Matthew MacDonald, noted author of Your Brain: The Missing Manual, takes you on a fascinating tour of your body from the outside in, beginning with your skin and progressing to your vital organs. You'll look at the quirks, curiosities, and shortcomings we've all learned to live with, and pick up just enough biology to understand how your body works. You'll learn: That you shed skin more frequently than snakes do Why the number of fat cells you have rarely changes, no matter how much you diet or exercise -- they simply get bigger or smaller How you can measure and control fat That your hair is made from the same stuff as horses' hooves That you use only a small amount of the oxygen you inhale Why blood pressure is a more important health measure than heart rate -- with four ways to lower dangerously high blood pressure Why our bodies crave foods that make us fat How to use heart rate to shape an optimal workout session -- one that's neither too easy nor too strenuous Why a tongue with just half a dozen taste buds can identify thousands of flavors Why bacteria in your gut outnumbers cells in your body -- and what function they serve Why we age, and why we can't turn back the clock What happens to your body in the minutes after you die Rather than dumbed-down self-help or dense medical text, Your Body: The Missing Manual is entertaining and packed with information you can use. It's a book that may well change your life. Reader comments for Your Brain: The Missing Manual, also by author Matthew MacDonald: "Popular books on the brain are often minefields of attractive but inaccurate information. This one manages to avoid most of the hype and easy faulty generalizations while providing easy to read and digest information about the brain. It has useful tricks without the breathless hype of many popular books."-- Elizabeth Zwicky, The Usenix Magazine "...a unique guide that should be sought after by any who want to maximize what they can accomplish with their mental abilities and resources."-- James A. Cox, The Midwest Book Review - Wisconsin Bookwatch "If you can't figure out how to use your brain after reading this guide, you may want to return your brain for another."-- The Sacramento Book Review, Volume 1, Issue 2, Page 19 "It's rare to find a book on any technical subject that is as well written and readable as Your Brain: The Missing Manual. The book covers pretty much anything you may want to know about your brain, from what makes it up, through how it develops to how to mitigate the affects of aging. The book is easy reading, fact packed and highlighted notes and practical applications. So if you want to learn more about your brain, how it works, how to get the best out of it or just want to stave off the ravages of Alzheimers (see chapter ten for details of how learning helps maintain your brain) then I can't recommend this book highly enough."-- Neil Davis, Amazon.co.uk "MacDonald's writing style is perfect for this kind of guide. It remains educational without becoming overly technical or using unexplained jargon. And even though the book covers a broad scope of topics, MacDonald keeps it well organized and easy to follow. The book captures your attention with fun facts and interesting studies that any person could apply to their own understanding of human ability. It has great descriptions of the brain and its interconnected parts, as well as providing full color pictures and diagrams to offer a better explanation of what the author is talking about."-- Janica Unruh, Blogcritics Magazine

Stem Cells

Stem Cells PDF

Author: Ariff Bongso

Publisher: World Scientific

Published: 2011

Total Pages: 721

ISBN-13: 9814289388

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Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications.

Molecular and Cellular Gerontology

Molecular and Cellular Gerontology PDF

Author: Olivier Toussaint

Publisher:

Published: 2000

Total Pages: 0

ISBN-13: 9781573312714

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This work covers a number of relevant aspects of the molecular and cellular biology of ageing, a timely general topic highlighted by the United Nations' having declared 1999 the Year of the Elderly. The papers published here represent a wide range of complementary research areas: molecular and cellular aspects; theories of ageing; molecular basis of the loss of homeostatic maintenance mechanisms; lower and higher model organisms including transgenic animal models; the genetics of human longevity; clinical and molecular aspects of age-related diseases; and integrated systems like brain and immune system aging. It is hoped that the additions to knowledge of the molecular mechanisms of ageing provided by this volume may ultimately lead to the prevention of age-related diseases.

Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Biochemistry and Cell Biology of Ageing: Part II Clinical Science PDF

Author: J. Robin Harris

Publisher: Springer

Published: 2019-03-19

Total Pages: 499

ISBN-13: 9811336814

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This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Toward Healthy Aging

Toward Healthy Aging PDF

Author: Priscilla Ebersole

Publisher: Mosby Incorporated

Published: 2008

Total Pages: 727

ISBN-13: 9780323047302

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As the most comprehensive resource on health promotion and maintenance for older adults and their families and caregivers, Toward Healthy Aging, 7th Edition includes the most current information you need to provide effective holistic care, promote healthy lifestyle choices, and address end-of-life issues. Grounded in the core competencies recommended by the AACN in collaboration with the Hartfound Institute for Geriatric Nursing and using Maslow's hierarchy of needs, this book includes complete coverage of both common and uncommon conditions in the older adult. Towards Healthy Aging also highlights key aging issues with sections devoted to basic physiologic needs, safety and security, the need to belong, self-esteem, and self-actualization. A strong focus on health and wellness emphasizes a positive approach to aging. Disease processes are discussed in the context of healthy adaptation, nursing support, and responsibilities. Careful attention to age, cultural, and gender differences are integrated throughout to help you remember these important considerations when caring for older adults. Up-to-date content on AIDS provides important information on addressing this growing concern among older adults. Consistent chapter is organization with objectives, case studies, critical thinking questions, research, and study questions make information easy to find and use. Assessment guidelines are incorporated throughout in helpful tables, boxes, and forms for quick access. Case studies at the end of most chapters explore realistic patient care scenarios to help you expand your knowledge and understanding. Resource lists and appendices provide opportunities for further research and study. With over 200 illustrations, the full-color design is engaging and easy to read. Healthy People 2010 boxes address healthy aging considerations. Evidence-Based Practice boxes help you incorporate the latest research findings into practice and advise you on how to avoid potentially harmful practices. A Nutritional Needs chapter includes the most current nutritional guidelines for older adults to help you better address patients' nutritional needs. Includes the latest scales and guidelines for assessing the gerontologic patient in the Health Assessment in Gerontological Nursing chapter. Expanded coverage of end-of-life issues helps you meet the needs of older adults and their families and caregivers during this difficult transition. Economics of aging discussions help you better understand the financial challenges your patients may face. The latest pharmacologic and nonpharmacologic pain management information helps you reduce pain and discomfort for your patients and helps you provide more effective care.