Advances in Peptic Ulcer Pathogenesis

Advances in Peptic Ulcer Pathogenesis PDF

Author: W.D. Rees

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 248

ISBN-13: 9400912455

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Over the past decade a great deal of research activity has occurred on either side of the gastroduodenal epithelial interface, with the common goal of elucidating the mechanisms of mucosal protection and how these may be compromised in peptic ulcer disease. A prime stimulus to such research has been the realization that abnormal acid secretion or its delivery into the duodenum in excessive amount cannot fully explain ulcer pathogenesis in the majority of patients. One may envisage the stomach and proximal duodenum as being in a dynamic equilibrium, with aggressive luminal factors, such as acid and pepsin, being counteracted by protective mucosal mechanisms. Until recently, the mechanisms involved in mucosal protection had been poorly defined while the physiology and pathophysiology of acid and pepsin secretion had been elucidated. The impression that gastroduodenal mucosa was protected by a single mechanism has at last been replaced by a more realistic view, suggesting a number of protective zones acting in series. Some of these zones may act as first or second line defences against aggressive factors while certain zones may specifically protect against certain aggressors.

Peptic Ulcers: Advances in Research and Treatment: 2011 Edition

Peptic Ulcers: Advances in Research and Treatment: 2011 Edition PDF

Author:

Publisher: ScholarlyEditions

Published: 2012-01-09

Total Pages: 23

ISBN-13: 1464959560

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Peptic Ulcers: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Peptic Ulcers in a compact format. The editors have built Peptic Ulcers: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Peptic Ulcers in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Peptic Ulcers: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Ulcer Disease

Ulcer Disease PDF

Author: Sandor Szabo

Publisher: CRC Press

Published: 1989-07-31

Total Pages: 494

ISBN-13: 9780849362163

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The latest data on the pathogenesis of ulcer disease is presented in this text, with the emphasis that an understanding of the pathogenesis and etiology of ulcer diseases represents the most rational approach to pharmacology - the prevention and treatment of ulcer disease. Early and late biochemical and functional changes, morphologic stages of the injury and healing phases, as well as vascular factors in ulceration are highlighted. In addition, new pathogenetic elements on neuroendocrine and other endogenous modulators and circadian rhythms in ulcerogenesis are covered. The section on new pharmacology consists of several chapters presenting new animal models of gastric, small intestinal and colonic ulcers because in vivo models represent the basis to test and accurately detect new antiulcer drugs. A large series of chapters cover new drugs for ulcer prevention and treatment. This book is indispensible to investigators in basic and applied research, academic and industrial pharmacologists and clinicians in gastroenterology.

Peptic Ulcer Disease: Basic and Clinical Aspects

Peptic Ulcer Disease: Basic and Clinical Aspects PDF

Author: G.F. Nelis

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 367

ISBN-13: 9400950349

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Despi te a slow decrease in the incidence of peptic ulcer in the Western world during the past decade, general practitioners, physicians, gastroenterologists, and surgeons deal with patients suffering from peptic ulcer and its complications almost daily. It has been estimated that some 10% of the population in the Western world becomes af flicted by peptic ulcer at least once and many of them have chronic relapsing disease. This lays a heavy burden on the amount of money which is spent in general health care. In recent years our understanding of peptic ulcer disease has in creased tremendously, but considerable gaps in our knowledge remain. Originally the increase in our knowledge has been stimulated by the development of fibre-optic endoscopy in the sixties, and later by the development of new surgical techniques and drugs in the seventies. New insights into the pathophysiology of the disease resulted from these developments and revived the scientific interest in peptic ulcer disease. However, the field remains complicated and the studies are be devilled by the large number of variables which can affect the results. In the symposium 'PEPTIC ULCER TODAY' we have attemp ted to bring together recent knowledge on basic and clinical aspects of peptic ulcer disease.

Peptic Ulcers—Advances in Research and Treatment: 2012 Edition

Peptic Ulcers—Advances in Research and Treatment: 2012 Edition PDF

Author:

Publisher: ScholarlyEditions

Published: 2012-12-26

Total Pages: 49

ISBN-13: 1481623192

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Peptic Ulcers—Advances in Research and Treatment: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Peptic Ulcers in a compact format. The editors have built Peptic Ulcers—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Peptic Ulcers in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Peptic Ulcers—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Peptic Ulcers—Advances in Research and Treatment: 2012 Edition

Peptic Ulcers—Advances in Research and Treatment: 2012 Edition PDF

Author:

Publisher: ScholarlyEditions

Published: 2012-12-26

Total Pages: 35

ISBN-13: 1481623184

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Peptic Ulcers—Advances in Research and Treatment: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Peptic Ulcers in a compact format. The editors have built Peptic Ulcers—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Peptic Ulcers in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Peptic Ulcers—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

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