Advances in Genetics and Molecular Diagnosis in Colorectal Cancer.
Author: Jorge Melendez-Zajgla
Publisher: Frontiers Media SA
Published: 2023-10-19
Total Pages: 135
ISBN-13: 2832536115
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Advances in genetics and molecular diagnosis in colorectal, stomach, and pancreatic cancer
Author: Carlos A. Vaccaro
Publisher: Frontiers Media SA
Published: 2023-01-27
Total Pages: 108
ISBN-13: 2832512127
DOWNLOAD EBOOK →DNA Alterations in Lynch Syndrome
Author: Matjaž Vogelsang
Publisher: Springer Science & Business Media
Published: 2013-11-19
Total Pages: 216
ISBN-13: 9400765975
DOWNLOAD EBOOK →Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
Molecular Genetics of Colorectal Neoplasia
Author: James M. Church
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 196
ISBN-13: 144199310X
DOWNLOAD EBOOK →Molecular Genetics of Colorectal Neoplasia A Primer for the Clinician provides the latest information on the genetics of colorectal cancer within a context of basic genetics, describing the subject in understandable language and making it clinically relevant. In this way, clinicians can become familiar with genetic terms and techniques related to colorectal neoplasia, providing a background upon which to build an appreciation of future advances and an ability to include them in the practicalities of patient care. This edition is intended for the healthcare provider or industry concerned with colorectal neoplasia: including general and colorectal surgeons, pathologists, oncologists, gastroenterologists, internal medicine and family practice physicians, nurses, geneticists, counsellors, registry co-ordinators, epidemiologists, and statisticians.
Molecular Pathogenesis of Colorectal Cancer
Author: Kevin M. Haigis, Ph.D.
Publisher: Springer Science & Business Media
Published: 2013-10-02
Total Pages: 319
ISBN-13: 146148412X
DOWNLOAD EBOOK →Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Advances in the Molecular Understanding of Colorectal Cancer
Author: Eva Segelov
Publisher: BoD – Books on Demand
Published: 2019-02-06
Total Pages: 174
ISBN-13: 1789850592
DOWNLOAD EBOOK →An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer.
Principles of Molecular Diagnostics and Personalized Cancer Medicine
Author: Dongfeng Tan
Publisher: Lippincott Williams & Wilkins
Published: 2012-12-07
Total Pages: 2177
ISBN-13: 1469820641
DOWNLOAD EBOOK →The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.
Genetics of Colorectal Cancer for Clinical Practice
Author: Fred H. Menko
Publisher: Springer Science & Business Media
Published: 1993-07-31
Total Pages: 210
ISBN-13: 9780792321002
DOWNLOAD EBOOK →Colorectal cancer is a collective term for a heterogeneous group of diseases. In a large proportion of cases, the condition is attributable to genetic predisposition. Those directly involved in the treatment of patients with cancer of the large bowel are confronted to an increasing degree with the genetic aspects of the disease. In familial and hereditary forms of the disorder periodic screening of the close relatives of the patients can in principle prevent disease and death from colorectal cancer. Presymptomatic diagnosis by means of DNA technology is now possible in many cases of familial adenomatous polyposis. Genetic diagnosis will be increasingly important for the identification of high-risk groups. This book summarizes those aspects of the genetics of colorectal cancer that are important for clinical pracice. It has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer. The aim of this book is to provide a guideline for the management of those situations in which the family history of colorectal cancer is found to be positive.
Genetics of Colorectal Cancer
Author: John D. Potter
Publisher: Springer
Published: 2008-12-08
Total Pages: 309
ISBN-13: 9780387095677
DOWNLOAD EBOOK →Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Novel Approaches to Colorectal Cancer
Author:
Publisher: Academic Press
Published: 2021-06-18
Total Pages: 486
ISBN-13: 0128240792
DOWNLOAD EBOOK →Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research Offers outstanding and original reviews on colorectal cancer research Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer
