Adrenergic Neurons
Author: Geoffrey Burnstock and Marcello Costa
Publisher: Springer
Published: 2013-11-27
Total Pages: 248
ISBN-13: 1489972625
DOWNLOAD EBOOK →Lanterna Rally
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The Release of Catecholamines from Adrenergic Neurons
Author: David M. Paton
Publisher: Elsevier
Published: 2016-06-06
Total Pages: 406
ISBN-13: 1483136523
DOWNLOAD EBOOK →The Release of Catecholamines from Adrenergic Neurons focuses on the processes involved in determining the release of catecholamines from neurons, noting the influence of alcohols, analgesics, and acids in the release. The selection first discusses biochemical and ultrastructural studies of the mechanism of release, as well as release of constituents of noradrenergic vesicles upon nerve stimulation; constituents of noradrenergic vesicles; and mechanism of release. The book then takes a look at the role of calcium in catecholamine release from adrenergic nerve terminals and presynaptic adrenoceptors and regulation of release. Topics include calcium-dependent versus calcium-independent noradrenaline release; differences between the presynaptic and postsynaptic alpha-adrenoceptors; and influence of neuronal uptake of noradrenaline on the negative feedback mechanism mediated by presynaptic alpha-adrenoceptors. The publication reviews presynaptic muscarine receptors and inhibition of release, including muscarinic inhibition of noradrenaline release evoked by electrical stimulation of sympathetic nerves; effect of muscarinic agonists on noradrenaline releasing procedures independent of calcium ions; and possible physiological and pharmacological significance of the muscarinic inhibitory mechanism. The text also ponders on the role of prostaglandins, cyclic adenosine monophate, analgesics, peptides, acids, anesthetics, and alcohols in the release. The selection is a dependable reference for readers interested in the study of the release of catecholamines from adrenergic neurons.
The alpha-1 Adrenergic Receptors
Author: Jr. Ruffolo
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 548
ISBN-13: 1461245826
DOWNLOAD EBOOK →During the past decade, great strides have been made in our un derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a prominent functional role in most organs of the body and in the key systems responsible for survival of the organism and maintenance of optimum biological activity. This is most apparent in the cardiovascular system, in which alpha-l adrenergic receptors are the single most important receptor involved in the maintenance of blood pressure and circu latory function. It is appropriate, therefore, that recent findings related to the pharmacology and biochemistry of the alpha-l adrenergic receptor be compiled, since this subject has not been reviewed in detail in recent years. It is the purpose of this book to present a series of reviews of key experimental findings that shed new light on the alpha-l adrenergic receptor and the manner in which it functions. Classically, most receptors have been characterized based on structure-activity relationships obtained for selective agonists and antagonists interacting with the receptor. Although there are many newer and more sophisticated approaches to receptor char acterization, structure-activity relationships still provide impor tant information regarding the chemical requirements made by the receptor for its occupation by ligands and its subsequent acti vation by those ligands possessing intrinsic efficacy and, there fore, agonist activity.
Advances in Adrenergic Receptor Biology
Author: Qin Wang
Publisher: Academic Press
Published: 2011-06-27
Total Pages: 257
ISBN-13: 0123849217
DOWNLOAD EBOOK →This volume of Current Topics in Membranes focuses on adrenergic receptor biology, beginning with a review of past successes and historical perspectives then further discussing current general trends in adrenic receptor studies in various contexts. This publication also includes discussions of the role and relationship of adrenergic receptors to different systems and diseases, establishing adrenergic receptor biology as a needed, practical reference for researchers.
The alpha-2 Adrenergic Receptors
Author: Lee E. Limbird
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 381
ISBN-13: 1461245966
DOWNLOAD EBOOK →Receptor Binding
Author: Alan A. Boulton
Publisher: Humana
Published: 1986-06-20
Total Pages: 616
ISBN-13:
DOWNLOAD EBOOK →Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscrentists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientists and 1s written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routinely across the widest range of s- drsciplines. Collecting these general techniques together in a single volume stnkes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of ammes and theirmetabolites and of amino acrds, respectively. These collections will clearly be of value to all neuroscientists working in or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques since experimental details are provided for many types of ligand-receptor binding, including chapters on general prin- ples, drug discovery and development, and a most useful app- dix on computer programs for Scatchard, nonlinear, and compe- tive displacement analyses. Volume 5 provides procedures for the assessment of enzymes involved in biogenic amine synthesis and catabolism. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physrologists, -anatomists, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analytical, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.
The Catecholaminergic Innervation of the Rat Amygdala
Author: Esther Asan
Publisher: Springer Science & Business Media
Published: 2013-03-12
Total Pages: 199
ISBN-13: 3642720854
DOWNLOAD EBOOK →Experimental evidence indicates that catecholamines are able to modulate information processing in the amygdaloid complex. The dense catecholaminergic innervation of the amygdala may thus exert significant influence upon its well-documented functions in emotion, attention, learning and memory. Dysfunctions of the systems have been suggested to be involved in the etiology of neuropsychiatric disorders including senile dementia, Parkinson's disease and schizophrenia. To further insight into neural mechanisms of the innervation, the present study provides a detailed documentation of ultrastructural and neurochemical characteristics of dopanminergic, noradrinergic and adrenergic afferent fibers and of their target structures in central, basal and intercalated amygdaloid nuclei. A high degree of heterogeneitiy is observed between the nuclei concerning the different catecholaminergic innervation patterns and the peptide content of individual catecholaminergic fibers, as well as concerning the neurotransmitter/-modulator and receptor expression of possible amygdaloid target neurons. The results are discussed with regard to previously documented properties of the nuclei.
Noradrenergic Neurons
Author: Marianne Fillenz
Publisher: Cambridge University Press
Published: 1990-05-25
Total Pages: 260
ISBN-13: 9780521287807
DOWNLOAD EBOOK →The Noradrenergic Neurons examines the mechanisms that regulate the release and synthesis of the neurotransmitter noradrenaline. Noradrenaline (or norepinephrine) and the physiological activity of the cells that manufacture and release it, play an important role in response to stress and the development of resistance to stress, as well as psychological mood itself. This book discusses the response of the various nonadrenergic receptor subtypes to noradrenaline, and the long-lasting changes that underlie the striking plasticity of function manifested by noradrenergic cells, which in turn are reflected in observable behavioral plasticity In recent years there has been no single book that presents an up-to-date synthesis of current knowledge on the biochemical, anatomical, and physiological aspects of this important group of brain and peripheral nervous system cells and their function in the whole behaving organism, and this book aims to fill that gap. This is informative reading for students of physiological psychology, neurochemistry, and medicine.
Pharmacology of Cholinergic and Adrenergic Transmission
Author: G. B. Koelle
Publisher: Elsevier
Published: 2017-01-31
Total Pages: 360
ISBN-13: 1483185397
DOWNLOAD EBOOK →Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 3: Pharmacology of Cholinergic and Adrenergic Transmission focuses on the effects of drugs on muscles, nerve fibers, and the central nervous system. The selection first offers information on the role of sodium ions in the release of acetylcholine and the distribution and release of acetylcholine in muscles. Discussions focus on the effects of sodium deficiency on ACh release in perfused ganglia; effects of sodium pump inhibitors on ganglionic and myoneural transmission; distribution of ACh and choline acetylase in muscle; and ACh release after denervation. The text then ponders on the roles of acetylcholine and acetylcholinesterase in junctional transmission and correlated studies of monoamines and acetylcholinesterase in sympathetic ganglia, manifesting the distribution of adrenergic and cholinergic neurons. The publication examines the action of acetylcholine and related drugs on mammalian nonmyelinated nerve fibers; possible mechanisms of acetylcholine action in muscles; and electrophysiological analysis of cholinergic transmission in sympathetic ganglia. The text then reviews the interactions of cholinomimetic and cholinergic blocking drugs at sympathetic ganglia; evolution of cholinoreceptive sites of locomotor muscle; and pharmacological blocking of central cholinoreactive systems and the possibilities of its therapeutic application. The selection is a dependable source of data for readers interested in the pharmacology of cholinergic and adrenergic transmission.
Adrenergic Activators and Inhibitors
Author:
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 1223
ISBN-13: 3642675050
DOWNLOAD EBOOK →Not much more than a decade has passed since the appearance of the outstanding handbook, Catecholamines, edited by BLASCHKO and MUSCHOLL, in the series: Handbook of Experimental Pharmacology. However, this extremely well organized volume dealt mainly with the origin, molecular actions, and fate of the naturally occuring catecholamines. It was felt that a separate volume should be dedicated to the remarkable and exciting progress made in the field of agents influencing the adrenergic system, both in physiologic and pharmacologic respect. The editor of the present volume considers himself lucky to have been able to persuade a number of eminent specialists to collaborate. The main concept of the present handbook is a systematic approach to the various effects of adrenergic activators and inhibitors starting with the chemistry and structure actitivity relationship, followed by the evaluation of adrenergic activators and inhibitors, and discussing their mode of action. The most voluminous part is the chapter dealing with the systemic pharma cology of these agents analyzing the effects on the central nervous system, on the autonomic nervous system, on the cardiovascular, the respiratory, the digestive, the endocrine system, on the skeletal muscle, and on metabolism. Kinetics and bio transformation, further toxic effects are discussed in the following chapters. A special chapter on clinical features concludes the monograph.
