Author: Ernesto Quagliariello
Publisher: Elsevier Science & Technology
Published: 1985
Total Pages: 504
ISBN-13:
DOWNLOAD EBOOK →Author: Ernesto Quagliariello
Publisher: Elsevier Science & Technology
Published: 1985
Total Pages: 568
ISBN-13: 9780444807472
DOWNLOAD EBOOK →Author: Ernesto Quagliariello
Publisher: Elsevier Science & Technology
Published: 1985
Total Pages: 504
ISBN-13:
DOWNLOAD EBOOK →Author: Anna Gvozdjáková
Publisher: Springer Science & Business Media
Published: 2008-02-01
Total Pages: 446
ISBN-13: 1402067143
DOWNLOAD EBOOK →Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.
Author: Justin C. St. John
Publisher: Springer Science & Business Media
Published: 2012-09-26
Total Pages: 190
ISBN-13: 1627031014
DOWNLOAD EBOOK →This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.