A Guide to Safety in the Pharmaceutical or Chemical Industry

A Guide to Safety in the Pharmaceutical or Chemical Industry PDF

Author: Dr. Shmmon Ahmad

Publisher: Kindle Direct Publishing

Published: 2023-10-14

Total Pages: 56

ISBN-13:

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After many years of industrial experience in the Pharmaceutical Industry, serving as a Quality Assurance Officer and Production Officer, I felt compelled to share my insights. Throughout my career in various manufacturing companies, I witnessed a series of mishaps, accidents, injuries, near misses, fires, and other incidents that underscored a critical issue. It became evident that even seasoned safety professionals often lacked a comprehensive understanding of the techniques, terminology, procedures, and systems essential for assessing, measuring, and applying the necessary tools to achieve the desired safety performance. My journey eventually led me to the role of an educator at Glocal University Saharanpur, where I taught Quality Assurance subjects. In my opinion, these subjects require continuous evaluation and updating to remain relevant in an ever-evolving industrial landscape. I firmly believe that certain topics hold paramount importance, particularly for safety professionals and management personnel responsible for safety management within their organizations. This book delves into topics such as management responsibility, attitudinal problems, behaviour, safety thinking, motivation for creating a safety culture, and communication challenges. These subjects are approached from a practical standpoint, making them readily applicable to day-to-day safety administration. While extensive information and literature exist on motivation and communication, their specific applications in the realm of occupational safety and loss prevention are relatively scarce. I aspire to offer this book as a valuable resource to safety professionals, safety advisors and representatives, and industry line managers to improving plant facility design, training for operation and maintenance staff, and the development of safe operating procedures. Its purpose is to unravel what has gone wrong in the past and provide guidance on preventing similar incidents in the future. Regrettably, history has shown that many incidents tend to recur after a few months, often due to people moving on and lessons being forgotten. Among the various teaching methods, experiential learning has proven the most effective, as it helps retain subject matter for an extended period. Should you come across an incident described in this book that appears to have taken place in your plant, please be aware that certain details may have been altered. This alteration is intended to make it challenging for readers to pinpoint the exact location of the incident or to simplify complex narratives without compromising the core message. In some cases, the incident may not have occurred in your plant at all; it may have taken place in a different facility facing similar circumstances."

Evaluating Process Safety in the Chemical Industry

Evaluating Process Safety in the Chemical Industry PDF

Author: J. S. Arendt

Publisher: John Wiley & Sons

Published: 2010-08-27

Total Pages: 108

ISBN-13: 0470935456

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Quantitative Risk Analysis is a powerful tool used to help manage risk and improve safety. When used appropriately, it provides a rational basis for evaluating process safety and comparing alternative safety improvements. This guide, an update of an earlier American Chemistry Council (ACC) publication utilizing the "hands-on" experience of CPI risk assessment practitioners and safety professionals involved with the CCPS and ACC, explains how managers and users can make better-informed decisions about QRA, and how plant engineers and process designers can better understand, interpret and use the results of a QRA in their plant.

Safety Audits

Safety Audits PDF

Author: Chemical Industry Safety and Health Council (Great Britain)

Publisher:

Published: 1973

Total Pages: 46

ISBN-13: 9780900623202

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Nonclinical Safety Assessment

Nonclinical Safety Assessment PDF

Author: William J. Brock

Publisher: John Wiley & Sons

Published: 2013-03-05

Total Pages: 492

ISBN-13: 1118516982

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Nonclinical Safety Assessment Nonclinical Safety Assessment A Guide to International Pharmaceutical Regulations Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a practical description of nonclinical drug development regulations and requirements in the major market regions. It includes: ICH – the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use National regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and Australia Repeated dose toxicity studies Carcinogenicity; Genotoxicity; Developmental and reproductive toxicology; Immunotoxicology Biotechnology-derived pharmaceuticals Vaccine development Phototoxicity and photocarcinogenicity Degradants, impurities, excipients and metabolites Primarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.

Guidelines for Risk Based Process Safety

Guidelines for Risk Based Process Safety PDF

Author: CCPS (Center for Chemical Process Safety)

Publisher: John Wiley & Sons

Published: 2011-11-30

Total Pages: 759

ISBN-13: 111820963X

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Guidelines for Risk Based Process Safety provides guidelines for industries that manufacture, consume, or handle chemicals, by focusing on new ways to design, correct, or improve process safety management practices. This new framework for thinking about process safety builds upon the original process safety management ideas published in the early 1990s, integrates industry lessons learned over the intervening years, utilizes applicable "total quality" principles (i.e., plan, do, check, act), and organizes it in a way that will be useful to all organizations - even those with relatively lower hazard activities - throughout the life-cycle of a company.

Safe Use of Chemicals

Safe Use of Chemicals PDF

Author: T.S.S. Dikshith

Publisher: CRC Press

Published: 2008-08-21

Total Pages: 312

ISBN-13: 9781420080520

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Occupational workers frequently use, store, and dispose of toxic chemicals without knowing the possible consequences, both for the workplace and the environment. Improper use or misuse of chemical substances can result in health disorders, fatalities, or chemical disasters. Safe Use of Chemicals: A Practical Guide presents quick and comprehensive i

The Management of Chemical Process Development in the Pharmaceutical Industry

The Management of Chemical Process Development in the Pharmaceutical Industry PDF

Author: Derek Walker

Publisher: John Wiley & Sons

Published: 2008-03-03

Total Pages: 424

ISBN-13: 0470259507

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Here is a practical guide that not only presents insights into the organization and management of the disciplines involved in chemical process development but also provides basic knowledge of these disciplines, enabling process development practitioners to recognize and assimilate them in their work. This book illustrates practical considerations through many examples of the successful direction and integration of the activities of chemists, analysts, chemical engineers, and biologists, as well as safety, regulatory, and environmental professionals in productive teams. Moreover, this reference provides guidance on: Directing and carrying out specific tasks and courses of action Making and communicating clear and achievable decisions Solving problems on the spot Managing the administrative aspects of chemical process development The author, Dr. Derek Walker, has directed chemical process development work for four decades, combining firsthand chemical synthesis experience with many other disciplines needed to create chemical processes. You will benefit from his advice and unique insights into: Understanding the workings of matrix organizations Defining missions and creating action plans Developing interdisciplinary approaches to problem solving Holding review meetings, revising goals, and motivating staff Prioritizing programs and responses to emergencies In addition, you'll learn how successful chemists, in collaboration with other disciplines, define the best (green) chemistry for process scale-up, including accommodating FDA requirements in the last process steps and addressing safety and environmental matters early in their work. Case studies provide incisive perspective on these issues. A chapter on recognizing and patenting intellectual property emphasizes the importance of comprehensive literature surveys and understanding invention. A chapter on the future challenges you to think beyond narrow constraints and explore new horizons.

Practical Guide to Industrial Safety

Practical Guide to Industrial Safety PDF

Author: Nicholas P. Cheremisinoff

Publisher: CRC Press

Published: 2000-10-12

Total Pages: 410

ISBN-13: 0824745345

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A practical guide to industrial safety. It seeks to assist specialists in managing operations in industrial settings, including high-risk personal exposure such as inhalation hazards and direct chemical contact. It covers hazards in the chemical process industries, inhalation hazards in refineries, indoor air quality management, personal protective equipment, process safety emergency preparedness, safety in the laboratory, and more. There are Web site listings, NFPA hazard ratings, and other sources of information.

Industrial Guide to Chemical and Drug Safety

Industrial Guide to Chemical and Drug Safety PDF

Author: T. S. S. Dikshith

Publisher: John Wiley & Sons

Published: 2003-05-27

Total Pages: 659

ISBN-13: 0471458775

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Exposure to a wide variety of chemicals and drugs has become common in industrial, laboratory, and even household environments. Fortunately, global understanding and consequently global safety standards regarding the management of toxic and hazardous substances are fast approaching uniformity. The methods of handling, use, transportation, storage, and disposal in particular are moving toward standardization. As these protocols involving chemicals and drugs continue to cross international borders, students and professionals need a reliable resource to ensure they observe appropriate safety standards. The Industrial Guide to Chemical and Drug Safety covers not only current standards, but also a wealth of information on toxins to help regulatory bodies develop new protocols. Written in an accessible narrative style, the Guide covers chemicals by key classes such as solvents, pesticides, and metals, and also by key industries such as drugs, food additives, plastics, cosmetics, detergents, and soaps. The book explains the beneficial and harmful aspects of a broad range of materials to which students, trainees, skilled workers, managers, and personnel associated with regulatory agencies are exposed, with the purpose of helping them avoid the illnesses associated with the misuse of chemicals and drugs. Chapters include: -Heavy Metals -Pesticides -Industrial Solvents -Industrial Gases and Fumes -Drugs -Target Organ Toxicity -Disposal of Hazardous Chemicals -Guidance to Students and Workers -Good Laboratory Practice