100 Key Clinical Trials
Author: Steven P. Marso
Publisher: Remedica Pub Limited
Published: 2007-04-01
Total Pages: 226
ISBN-13: 9781905721009
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Clinical Trials
Author: Lorna Speid, Ph.D
Publisher: Oxford University Press
Published: 2010-07-30
Total Pages: 208
ISBN-13: 0199750599
DOWNLOAD EBOOK →Every year, hundreds of thousands of healthy volunteers and patients worldwide undertake the journey through the maze that can be clinical trials. Research participants take part in clinical trials for a variety of reasons. The healthy volunteers may be seeking extra money to pay off college tuition, or they may know someone who is suffering and would potentially benefit from the results of the trial. The patient who is terminally ill might participate in a clinical trial simply as a last hope for a cure. Whatever the goals, though, most participants will experience the same sense of bewilderment as they encounter the jargon and medical terminology that they will hear and have to read about and understand during the course of the clinical trial. Clinical Trials: What Patients and Volunteers Need to Know demystifies the entire process, focusing on the process of drug development, and the clinical trial itself. Writing from a lifetime of experience, the author provides important questions to ask those running a clinical trial, key definitions and terms for a participant to know and understand, as well as anecdotes illustrating the clinical trial process. The author also grapples with the idea of "informed consent," providing mechanisms for patients and volunteers to feel fully informed before signing up for the trial. A vital resource for those who are considering enrolling in a clinical trial, or for the parents, friends, or relatives of those involved in a clinical trial, this book takes away the mystery and allows the participant to enter a clinical trial feeling both informed and confident.
Randomized Clinical Trials
Author: David Machin
Publisher: John Wiley & Sons
Published: 2010-05-20
Total Pages: 375
ISBN-13: 0470319224
DOWNLOAD EBOOK →Using examples and case studies from industry, academia and research literature, Randomized Clinical Trials provides a detailed overview of the key issues involved in designing, conducting, analysing and reporting randomized clinical trials. It examines the methodology for conducting Phase III clinical trials, developing the protocols, the practice for capturing, measuring, and analysing the resulting clinical data and their subsequent reporting. Randomized clinical trials are the principal method for determining the relative efficacy and safety of alternative treatments, interventions or medical devices. They are conducted by groups comprising one or more of pharmaceutical and allied health-care organisations, academic institutions, and charity supported research groups. In many cases such trials provide the key evidence necessary for the regulatory approval of a new product for future patient use. Randomized Clinical Trials provides comprehensive coverage of such trials, ranging from elementary to advanced level. Written by authors with considerable experience of clinical trials, Randomized Clinical Trials is an authoritative guide for clinicians, nurses, data managers and medical statisticians involved in clinical trials research and for health care professionals directly involved in patient care in a clinical trial context.
Methods and Applications of Statistics in Clinical Trials, Volume 1
Author: Narayanaswamy Balakrishnan
Publisher: John Wiley & Sons
Published: 2014-03-05
Total Pages: 937
ISBN-13: 1118595912
DOWNLOAD EBOOK →A complete guide to the key statistical concepts essential for the design and construction of clinical trials As the newest major resource in the field of medical research, Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs presents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial design and analysis. Accessible and comprehensive, the first volume in a two-part set includes newly-written articles as well as established literature from the Wiley Encyclopedia of Clinical Trials. Illustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I-IV trials. Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs also features: Detailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials Over 100 contributions from leading academics, researchers, and practitioners An exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs is an excellent reference for researchers, practitioners, and students in the fields of clinicaltrials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology,and public health.
Fast Facts: Medical Statistics
Author: R. Kay
Publisher: Karger Medical and Scientific Publishers
Published: 2020-07-17
Total Pages: 110
ISBN-13: 1912776685
DOWNLOAD EBOOK →Using real examples from oncology trials, but keeping it simple, this concise resource explains the basic principles of medical statistics so that you can better appraise clinical trial results. Key concepts covered in this book include: • hypothesis testing • Kaplan–Meier curves and other graphic representations of data • calculating the power of a study • the stopping rules for efficacy and futility. ' Fast Facts: Medical Statistics' is aimed at all clinicians, clinical scientists, medical writers and regulatory personnel who need a better understanding of the statistical terms and methods used in the planning of studies and the analysis of clinical trial data. If you have ever wanted to know what a type I error is, how an odds ratio is calculated or what a forest plot is really all about, then this is the book for you. Contents: • Statistical inference • Analysis of time-to-event endpoints • Power and sample size • Multiplicity • Interim analysis • Modeling • Graphical methods
Designing Clinical Research
Author: Stephen B. Hulley
Publisher: Lippincott Williams & Wilkins
Published: 2011-11-30
Total Pages: 388
ISBN-13: 1451165854
DOWNLOAD EBOOK →Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop. Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.
Emergency Medicine Evidence
Author: Emily L. Aaronson
Publisher: Lippincott Williams & Wilkins
Published: 2014-08-08
Total Pages: 463
ISBN-13: 1469899876
DOWNLOAD EBOOK →Ramp up your knowledge of the clinical trials and evidence that laid the groundwork for current emergency practice with Emergency Medicine Evidence: The Practice-Changing Studies. Brief, easy-to-read, and accessible, this time-saving quick-reference allows you to quickly familiarize yourself with the 100 most practice-changing clinical trials in emergency medicine. Features Master key information through one-page synopses of the 100 most-practicing changes clinical trials in emergency medicine. Explore landmark clinical trials in all areas of emergency medicine, including abdominal, airway, allergy, cardiology, endocrine, infectious disease, neurology, operations, orthopedics, pain, PE/DVT, psychiatry, pulmonary, toxicology, trauma, and ultrasound. Access crucial information you need to enter the world of evidence-based emergency medicine. Key findings in practical tips and commentary to improve your study
Fast Facts: Clinical Trials in Oncology
Author: A. Hackshaw
Publisher: Karger Medical and Scientific Publishers
Published: 2020-12-18
Total Pages: 120
ISBN-13: 191277674X
DOWNLOAD EBOOK →Written by leading experts, 'Fast Facts: Clinical Trials in Oncology' will enhance the reader’s ability to critically evaluate published evidence. Assuming little or no prior knowledge, the book sets out clearly the fundamental features of clinical trials. The key attributes of Phase I–III trials of pharmaceutical products are described, as are trials of surgical procedures, radiation therapy and advanced therapies. The processes and documentation required to set up and conduct a trial are outlined, and the authors describe how trial data and real-world evidence are used to improve care. Although this concise colorful book focuses on oncology, the principles apply equally to interventions in other areas of practice. It will prove invaluable to medical, pharmaceutical and allied health professionals who want, or need, an overview of how contemporary clinical trials are designed and conducted.
Fundamentals of Clinical Trials
Author: Lawrence M. Friedman
Publisher: Springer Science & Business Media
Published: 1998
Total Pages: 384
ISBN-13: 9780387985862
DOWNLOAD EBOOK →This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.
Practical Drug Safety from A to Z
Author: Barton Cobert
Publisher: Jones & Bartlett Publishers
Published: 2009-10-06
Total Pages: 406
ISBN-13: 0763745278
DOWNLOAD EBOOK →The Practical Drug Safety from A to Z is an alphabetical guide to drug safety monitoring (pharmacovigilance), covering literally, the "A to Z" of maintaining drug safety. Written by experts in the field, this book is a perfect to companion to the Manual of Drug Safety and Pharmacovigilance and an essential reference for pharmacists, pharmacologists, hospital administrators, medical liability lawyers, and others.
